New Insights into the Pathogenesis and Treatment of Rheumatoid Arthritis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Free radicals, antioxidants, and human disease: where are we now?

1992 • 2,223 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Rheumatoid Arthritis

1990 • 1,565 citations

Biology of interleukin 1

1988 • 1,547 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1993 • 1,031 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

1970 • 981 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1990 • 963 citations

Identification and characterization of a novel monocyte subpopulation in human peripheral blood

1989 • 941 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis

1995 • 917 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

1992 • 728 citations

Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.

1986 • 709 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Hematopoietic growth factors.

1987 • 621 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

LONG-TERM OUTCOME OF TREATING RHEUMATOID ARTHRITIS: RESULTS AFTER 20 YEARS

1987 • 593 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator

1985 • 566 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Multiple actions of interleukin 6 within a cytokine network

1988 • 536 citations

Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

1987 • 527 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Peptide Regulatory Factors

1989 • 498 citations

Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.

1986 • 496 citations

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

1990 • 493 citations

CORRELATION OF PLASMA INTERLEUKIN 1 LEVELS WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

1988 • 490 citations

Hematopoietic Growth Factors

1989 • 465 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes

1990 • 438 citations

Mortality in rheumatoid arthritis

1995 • 407 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Effects of Interleukin-1 on Bone Turnover in Normal Mice*

1989 • 366 citations

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

1987 • 363 citations

A urine inhibitor of interleukin 1 activity that blocks ligand binding.

1987 • 351 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

1985 • 325 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Tumor necrosis factor provokes superoxide anion generation from neutrophils

1986 • 307 citations

Nitric oxide and arthritis

1993 • 299 citations

Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody.

1991 • 295 citations

HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT

1989 • 290 citations

Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α

1991 • 290 citations

Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions.

1989 • 265 citations

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.

1990 • 264 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Function and heterogeneity of human Fc receptors for immunoglobulin G.

1989 • 251 citations

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

1988 • 244 citations

Regulation of IgG1 and IgE Production by Interleukin 4

1988 • 244 citations

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

1988 • 243 citations

Serum antioxidants and risk of rheumatoid arthritis.

1994 • 231 citations

Tumor Necrosis Factor-α (Cachectin) Stimulates Bone Resorption in Mouse Calvaria via a Prostaglandin-Mediated Mechanism*

1987 • 229 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules

1985 • 227 citations

Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients

1984 • 224 citations

GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism

1988 • 219 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

1994 • 214 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

IL-4 inhibits superoxide production by human mononuclear phagocytes.

1990 • 211 citations

Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.

1990 • 208 citations

Circadian rhythm of serum interleukin-6 in rheumatoid arthritis.

1994 • 206 citations

Interleukin 4 inhibition of prostaglandin E2 synthesis blocks interstitial collagenase and 92-kDa type IV collagenase/gelatinase production by human monocytes.

1992 • 204 citations

Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.

1991 • 204 citations

Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor.

1992 • 200 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor.

1987 • 194 citations

Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors.

1983 • 193 citations

Does Drug Therapy Slow Radiographic Deterioration in Rheumatoid Arthritis?

1983 • 189 citations

Angiogenesis inhibition suppresses collagen arthritis.

1992 • 188 citations

Increased nitric oxide levels in patients with rheumatoid arthritis.

1996 • 187 citations

Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

1994 • 186 citations

Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment

1989 • 185 citations

Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin‐4 in an ex vivo model of rheumatoid synovitis

1992 • 184 citations

Low levels of interleukin‐4 and high levels of transforming growth factor β in rheumatoid synovitis

1990 • 181 citations

Determination of cytokines in synovial fluids: correlation with diagnosis and histomorphological characteristics of synovial tissue.

1992 • 177 citations

Oxygen radicals, inflammation, and arthritis: Pathophysiological considerations and implications for treatment

1991 • 174 citations

Immunosuppression induced by nitric oxide and its inhibition by interleukin‐4

1992 • 172 citations

Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.

1992 • 172 citations

CD16. Developmentally regulated IgG Fc receptors on cultured human monocytes.

1988 • 170 citations

The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells

1993 • 170 citations

Cachectin (Tumor Necrosis Factor)

1988 • 170 citations

Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.

1989 • 166 citations

The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis

1993 • 163 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

Tumors Producing Human Tumor Necrosis Factor Induce Hypercalcemia and Osteoclastic Bone Resorption in Nude Mice*

1989 • 154 citations

The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA)

1985 • 154 citations

Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro

1985 • 150 citations

Inhibition of cartilage proteoglycan synthesis by interleukin 1

1988 • 146 citations

Cytokine production in the rheumatoid joint: implications for treatment.

1990 • 144 citations

The possible role of neutrophil proteinases in damage to articular cartilage

1978 • 142 citations

Circulating soluble tumor necrosis factor receptors, interleukin‐2 receptors, tumor necrosis factor α, and interleukin‐6 levels in rheumatoid arthritis.

1993 • 142 citations

Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

1990 • 141 citations

Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2.

1989 • 136 citations

Comparison of the Bone-Resorbing Activity in the Supernatants from Phytohemagglutinin-Stimulated Human Peripheral Blood Mononuclear Cells with That of Cytokines Through the Use of an Antiserum to Inter leukin 1*

1987 • 136 citations

Levels of circulating tumor necrosis factor α and interleukin‐6 in patients with rheumatoid arthritis. relationship to serum levels of hyaluronan and antigenic keratan sulfate

1993 • 135 citations

Effects of Tumor Necrosis Factor on Bone Formationin Vitro*

1987 • 134 citations

Role of cytokines in inflammatory synovitis

1990 • 132 citations

Transforming growth factor-beta and cellular immune responses in synovial fluids.

1990 • 129 citations

Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluid

1980 • 129 citations

ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats.

1991 • 129 citations

The leukemia inhibitory factor (LIF)

1991 • 127 citations

Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis.

1992 • 127 citations

Selective induction of Fc gamma RIII on human monocytes by transforming growth factor-beta.

1990 • 124 citations

Levels of circulating collagenase, stromelysin‐1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis: relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation

1995 • 123 citations

Tumor Necrosis Factor-α Inhibits Collagen Synthesis and Alkaline Phosphatase Activity Independently of Its Effect on Deoxyribonucleic Acid Synthesis in Osteoblast-Enriched Bone Cell Cultures*

1988 • 119 citations

Characteristics of tumor necrosis factor production in rheumatoid arthritis

1989 • 115 citations

Synovial localization of tumor necrosis factor in patients with rheumatoid arthritis

1988 • 114 citations

The effect of leukemia inhibitory factor on bone in vivo.

1993 • 114 citations

Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium.

1990 • 112 citations

Interleukin‐4 inhibits bone resorption through an effect on osteoclasts and proinflammatory cytokines in an ex vivo model of bone resorption in rheumatoid arthritis

1994 • 107 citations

Mechanisms of Methotrexate Action in Rheumatoid Arthritis

1994 • 106 citations

Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta

1992 • 103 citations

Effects of tumor necrosis factor α and β on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes

1990 • 103 citations

The superoxide generating system of B cell lines. Structural homology with the phagocytic oxidase and triggering via surface Ig.

1988 • 100 citations

Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vivo.

1991 • 99 citations

Induction of cytokine expression by leukemia inhibitory factor.

1993 • 99 citations

Cytokine expression in rheumatoid arthritis.

1991 • 94 citations

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1992 • 93 citations

Action of Plasmin on Cartilage

1958 • 91 citations

Inhibition of proteoglycan synthesis by hydrogen peroxide in cultured bovine articular cartilage

1985 • 87 citations

Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by interleukin-4.

1995 • 85 citations

Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus.

1983 • 85 citations

THE ROLE OF IL-4 AND IL-6 IN IL-1-DEPENDENT CARTILAGE MATRIX DEGRADATION

1995 • 84 citations

Circulating cytokine levels in patients with rheumatoid arthritis: results of a double blind trial with sulphasalazine.

1992 • 83 citations

Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator

1988 • 81 citations

The role of cytokines in the regulation of local bone resorption.

1991 • 78 citations

The detection and initial characterization of colony-stimulating factors in synovial fluid.

1988 • 75 citations

Effects of transforming growth factor β1 on the regulation of osteoclastic development and function

1991 • 73 citations

Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides

1993 • 72 citations

Leukemia inhibitory factor/differentiation‐stimulating factor (LIF/D‐factor): Regulation of its production and possible roles in bone metabolism

1992 • 69 citations

Leukemia Inhibitory Factor Suppresses Proliferation, Alkaline Phosphatase Activity, and Type I Collagen Messenger Ribonucleic Acid Level and Enhances Osteopontin mRNA Level in Murine Osteoblast-Like (MC3T3E1) Cells

1990 • 68 citations

The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.

1990 • 68 citations

Phase II Studies of Recombinant Human Interleukin-4 in Advanced Renal Cancer and Malignant Melanoma

1994 • 67 citations

Differential expression of Ia antigens by rheumatoid synovial lining cells.

1987 • 62 citations

Interleukin-1β induces synthesis and secretion of interleukin-6 in human chondrocytes

1990 • 62 citations

Arthritis induced by interleukin-1 is dependent on the site and frequency of intraarticular injection

1990 • 62 citations

The paradox of effective therapies but poor long-term outcomes in rheumatoid arthritis

1992 • 61 citations

Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation

1994 • 58 citations

Synthesis of Type II Collagen is Decreased in Cartilage Cultured with Interleukin 1 while the Rate of Intracellular Degradation Remains Unchanged

1988 • 58 citations

Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha.

1993 • 56 citations

Mechanism of immune complex‐mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon‐γ and tumor necrosis factor‐α

1989 • 55 citations

Interleukin‐4 but not interleukin‐10 inhibits the production of leukemia inhibitory factor by rheumatoid synovium and synoviocytes

1994 • 55 citations

Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages

1994 • 55 citations

Interleukin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid.

1995 • 54 citations

The effects of methotrexate on interleukin 1 in patients with rheumatoid arthritis.

1992 • 51 citations

Oxygen-centred free radicals can efficiently degrade the polypeptide of proteoglycans in whole cartilage

1984 • 51 citations

ROLE OF TNFα, IN RELATION TO IL-1 AND IL-6 IN THE PROTEOGLYCAN TURNOVER OF HUMAN ARTICULAR CARTILAGE

1991 • 49 citations

Mechanisms of erythroid suppression in the anemia of chronic disease.

1987 • 48 citations

Inhibition of nitric oxide synthesis by interleukin‐4 may involve inhibiting the activation of protein kinase C epsilon

1994 • 48 citations

Up‐regulation by tumor necrosis factor α of intercellular adhesion molecule 1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids

1993 • 46 citations

Interleukin-4, an inhibitor of cartilage breakdown in bovine articular cartilage explants.

1995 • 44 citations

Elevations in synovial fluid plasminogen activator in patients with rheumatoid arthritis.

1984 • 44 citations

Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity

1992 • 43 citations

Effects of transforming growth factor-beta and IL-1 alpha on prostaglandin synthesis in serum-deprived osteoblastic cells.

1991 • 42 citations

Effects of tumor necrosis factor alpha (TNF-alpha) on collagen arthritis.

1992 • 42 citations

T Lymphocyte Adhesion to Human Synovial Fibroblasts. Role of Cytokines and the Interaction Between Intercellular Adhesion Molecule 1 and CD11a/CD18

1991 • 41 citations

Production of leukemia inhibitory factor by human articular chondrocytes and cartilage in response to interleukin‐1 and tumor necrosis factor α

1993 • 40 citations

Anaemia of chronic disease in rheumatoid arthritis: effect of the blunted response to erythropoietin and of interleukin 1 production by marrow macrophages.

1992 • 38 citations

Vitamins A and E, retinol binding protein and zinc in rheumatoid arthritis.

1989 • 38 citations

IL-4 antagonizes induction of Fc gamma RIII (CD16) expression by transforming growth factor-beta on human monocytes.

1991 • 36 citations

Effect of interleukin-1-β and tumor necrosis factor-α on cartilage proteoglycan metabolismin vitro

1989 • 36 citations

Erythrocyte antioxidant enzymes are reduced in patients with rheumatoid arthritis.

1988 • 33 citations

Anti-Inflammatory Activity of Superoxide Dismutases: Comparison of Enzymes from Different Sources in Different Models in Rats: Mechanism of Action

1986 • 32 citations

Hematuria in patients with rheumatoid arthritis receiving gold and D-penicillamine.

1987 • 26 citations

Cachectin: A Pluripotent Hormone Released during the Host Response to Invasion

1987 • 23 citations

Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

1993 • 22 citations

Drug derived radicals: mediators of the side effects of anti-inflammatory drugs?

1992 • 20 citations

Chondrocyte-mediated breakdown of cartilage.

1987 • 20 citations

Inhibition by Interleukin-4 of Stromelysin Expression in Human Skin Fibroblasts: Role of PKC

1996 • 19 citations

The effect of IL-4 on human nasal mucosal responses

1992 • 13 citations

Similar regulation of chondrocyte functions by cellular stimulants of unknown mechanism

1990 • 10 citations

Molecular insights into rheumatoid arthritis

1991 • 8 citations

Recombinant human interleukin‐4 inhibits the production of granulocyte‐macrophage colony stimulating factor by blood mononuclear cells

1994 • 7 citations

Methotrexate in rheumatoid arthritis: can current knowledge and experience justify its use as a first-line disease-modifying agent?

1993 • 5 citations

Dithiocarbamates inhibit IL-1-induced cartilage degradation in bovine articular cartilage explants

1996 • 3 citations

Possible scavenger effect of salicylic acid on nitric oxide production in vitro

1992 • 2 citations

Deleted Work

1955 • 0 citations