Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

THERAPEUTIC CRITERIA IN RHEUMATOID ARTHRITIS

1949 • 2,904 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

1986 • 674 citations

RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION

1981 • 670 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta.

1985 • 505 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Tumor necrosis factor provokes superoxide anion generation from neutrophils

1986 • 307 citations

Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.

1981 • 160 citations

Rheumatoid Arthritis: Evolving Concepts of Pathogenesis and Treatment

1984 • 152 citations

Cytostatic and cytotoxic activity of tumor necrosis factor on human cancer cells.

1987 • 152 citations

Interleukin‐1 lymphocyte chemotactic activity in rheumatoid arthritis synovial fluid

1986 • 115 citations

Therapeutic criteria in rheumatoid arthritis

2001 • 46 citations