Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The biology of interleukin-6

1989 • 1,964 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

1988 • 273 citations

Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor.

1989 • 272 citations

Active and latent forms of transforming growth factor beta activity in synovial effusions.

1989 • 258 citations

Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis.

1991 • 256 citations

Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis.

1988 • 249 citations

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

1991 • 208 citations

Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.

1992 • 183 citations

Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia

1989 • 164 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

Properties Of The Novel Proinflammatory Supergene Intercrine Cytokine Family

1991 • 136 citations

Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

1990 • 134 citations

Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid.

1992 • 131 citations

Transforming growth factor-beta and cellular immune responses in synovial fluids.

1990 • 129 citations

The leukemia inhibitory factor (LIF)

1991 • 127 citations

Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

1991 • 117 citations

Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.

1988 • 107 citations

Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

1990 • 103 citations

IL-6 production by human T lymphocytes. Expression in HTLV-1-infected but not in normal T cells.

1991 • 96 citations

Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors

1991 • 87 citations

Leukemia Inhibitory Factor Suppresses Proliferation, Alkaline Phosphatase Activity, and Type I Collagen Messenger Ribonucleic Acid Level and Enhances Osteopontin mRNA Level in Murine Osteoblast-Like (MC3T3E1) Cells

1990 • 68 citations

Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin 6 and interferon gamma.

1990 • 63 citations

Leukemia Inhibitory Factor Binds with High Affinity to Preosteoblastic RCT-1 Cells and Potentiates the Retinoic Acid Induction of Alkaline Phosphatase

1990 • 58 citations

A myelosclerotic syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor (LIF).

1989 • 57 citations

Production of human interleukin for DA cells (HILDA)/leukemia inhibitory factor (LIF) by activated monocytes

1990 • 54 citations

Macrophage Differentiation Inducing Factor from Human Monocytic Cells Is Equivalent to Murine Leukemia Inhibitory Factor

1989 • 50 citations

Expression of leukemia inhibitory factor is regulated in human mesenchymal cells.

1991 • 38 citations

Interleukin‐6 and transforming growth factor‐β synergistically stimulate chondrosarcoma cell proliferation

1991 • 36 citations

Leukemia Inhibitory Factor: Does the Cap Fit?^a

1991 • 14 citations

Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

1991 • 8 citations

Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors

1991 • 6 citations

Deleted Work

1955 • 0 citations