Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin

MAP kinase signalling pathways in cancer

2007 • 2,757 citations

The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

2006 • 1,247 citations

The MEK/ERK cascade: From signaling specificity to diverse functions

2006 • 900 citations

ERK implication in cell cycle regulation

2006 • 712 citations

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

1999 • 688 citations

The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

1999 • 592 citations

Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

2007 • 560 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

Vagaries of conditional gene targeting

2007 • 399 citations

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

2008 • 347 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

2000 • 307 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Ras gene mutation and amplification in human nonmelanoma skin cancers

1991 • 276 citations

More than one way to skin . . .

2008 • 218 citations

Novel MEK1 Mutation Identified by Mutational Analysis of Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma

2008 • 208 citations

RalGDS is required for tumor formation in a model of skin carcinogenesis

2005 • 174 citations

Mek2 Is Dispensable for Mouse Growth and Development

2003 • 172 citations

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1998 • 154 citations

Cre activity causes widespread apoptosis and lethal anemia during embryonic development

2007 • 144 citations

Mek1/2 MAPK Kinases Are Essential for Mammalian Development, Homeostasis, and Raf-Induced Hyperplasia

2007 • 139 citations

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

1993 • 123 citations

Ras-dependent activation of the small GTPase Ral

1998 • 112 citations

Oncogenic signaling of class I PI3K isoforms

2007 • 103 citations

Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

2002 • 93 citations

Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy

2007 • 92 citations

Inducible activation of Ras and Raf in adult epidermis.

2003 • 81 citations

Requirement forMap2k1(Mek1) in extra-embryonic ectoderm during placentogenesis

2006 • 80 citations

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

2008 • 76 citations

Mek1 Alters Epidermal Growth and Differentiation

2004 • 73 citations

Progress Towards Therapeutic Small Molecule MEK Inhibitors for Use in Cancer Therapy

2005 • 71 citations

Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors

2007 • 66 citations

An unexpected new role of mutant Ras: perturbation of human embryonic development

2007 • 56 citations

MAP kinase: It’s been longer than fifteen minutes

2008 • 38 citations

Measuring Ras-family GTP levels in vivo—running hot and cold

2005 • 36 citations

Phosphorelay signalling: New tricks for an ancient pathway

1998 • 25 citations

The level of oncogene H-Ras correlates with tumorigenicity and malignancy

2008 • 5 citations

Histological and proteomic analysis of reversible H-Ras V12G expression in transgenic mouse skin

2007 • 5 citations

Biochemical and Biological Characterization of Tumor‐Associated Mutations of p110α

2008 • 4 citations