Mek1 Alters Epidermal Growth and Differentiation

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1999 • 850 citations

Understanding Ras: ‘it ain’t over ’til it’s over’

2000 • 785 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

The Raf/MEK/ERK pathway: new concepts of activation

2001 • 716 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

Transcriptional regulation by the MAP kinase signaling cascades

2003 • 482 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice.

1989 • 365 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo

2002 • 264 citations

KSR modulates signal propagation within the MAPK cascade.

1996 • 252 citations

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

2001 • 210 citations

A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment

2001 • 196 citations

Mek2 Is Dispensable for Mouse Growth and Development

2003 • 172 citations

Corrective gene transfer in the human skin disorder lamellar ichthyosis

1996 • 166 citations

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

2001 • 164 citations

Mitogen-activated Protein Kinase Kinase 2 Activation Is Essential for Progression through the G2/M Checkpoint Arrest in Cells Exposed to Ionizing Radiation

1999 • 134 citations

Ras-independent Activation of the Raf/MEK/ERK Pathway upon Calcium-induced Differentiation of Keratinocytes

2000 • 103 citations

Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

2002 • 93 citations

Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha.

1994 • 83 citations

Inducible activation of Ras and Raf in adult epidermis.

2003 • 81 citations

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

2000 • 76 citations

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.

1996 • 62 citations

Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals.

1983 • 61 citations

p19^ARF‐independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

2001 • 59 citations

Multistage carcinogenesis in the skin.

1996 • 50 citations

Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox.

1996 • 16 citations