Novel MEK1 Mutation Identified by Mutational Analysis of Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma

Cancer Statistics, 2007

2007 • 7,372 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Germline KRAS mutations cause Noonan syndrome

2006 • 729 citations

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers

2005 • 640 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

2004 • 588 citations

Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor

2007 • 556 citations

Germline Mutations in Genes Within the MAPK Pathway Cause Cardio-facio-cutaneous Syndrome

2006 • 549 citations

PIK3CA mutation status in Japanese lung cancer patients

2006 • 273 citations

Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F

2007 • 129 citations

Mutation and phenotypic spectrum in patients with cardio‐facio‐cutaneous and Costello syndrome

2007 • 105 citations

Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy

2007 • 92 citations

Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4

2007 • 88 citations

Leukemia in Cardio-facio-cutaneous (CFC) Syndrome: A Patient With a Germline Mutation in BRAF Proto-oncogene

2007 • 60 citations

Hepatoblastoma and heart transplantation in a patient with cardio‐facio‐cutaneous syndrome

2007 • 47 citations

Rhabdomyosarcoma in a Patient With Cardio-Facio-Cutaneous Syndrome

1999 • 31 citations

RAS Signalling Is Abnormal in a c-raf1 MEK1 Double Mutant

1995 • 30 citations