Role of myeloid cells in tumor angiogenesis and growth

Inflammation and cancer

2002 • 14,174 citations

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

2004 • 10,779 citations

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

2004 • 3,543 citations

Nitric oxide and the immune response

2001 • 3,222 citations

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

2007 • 3,082 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer

2007 • 3,010 citations

Macrophage activation and polarization

2007 • 2,948 citations

Angiogenesis as a therapeutic target

2005 • 2,543 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

A cytokine-mediated link between innate immunity, inflammation, and cancer

2007 • 1,867 citations

Tumor Angiogenesis

2008 • 1,854 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

2005 • 1,578 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

Vasculogenesis

1995 • 1,344 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Lymphangiogenesis in development and human disease

2005 • 1,225 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

2006 • 1,122 citations

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

2004 • 1,111 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Cancer immunoediting from immune surveillance to immune escape

2007 • 1,026 citations

Celecoxib for the Prevention of Sporadic Colorectal Adenomas

2006 • 1,019 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

2005 • 901 citations

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

2008 • 882 citations

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

2002 • 879 citations

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

2006 • 864 citations

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

2007 • 831 citations

Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type

2006 • 782 citations

Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels

2007 • 765 citations

Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression

2005 • 752 citations

Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells

2007 • 718 citations

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

2008 • 641 citations

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

2007 • 614 citations

Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors

2006 • 572 citations

Identification of an angiogenic mitogen selective for endocrine gland endothelium

2001 • 549 citations

Endogenous Inhibitors of Angiogenesis

2005 • 547 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Tumour immunity: effector response to tumour and role of the microenvironment

2008 • 511 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

2008 • 420 citations

Macrophage Responses to Hypoxia

2005 • 405 citations

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

2008 • 394 citations

Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization

2007 • 392 citations

Migratory neighbors and distant invaders: tumor-associated niche cells

2008 • 379 citations

Classical and alternative activation of mononuclear phagocytes: Picking the best of both worlds for tumor promotion

2006 • 359 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

Immature myeloid cells and cancer-associated immune suppression

2002 • 304 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

2008 • 299 citations

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

2003 • 289 citations

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

2004 • 284 citations

Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

2007 • 277 citations

Identification of Two Prokineticin cDNAs: Recombinant Proteins Potently Contract Gastrointestinal Smooth Muscle

2001 • 270 citations

Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy

2007 • 265 citations

Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

1998 • 253 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

Targeting VEGF-A to Treat Cancer and Age-Related Macular Degeneration

2006 • 231 citations

Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization

2004 • 221 citations

Alternative Macrophage Activation-Associated CC-Chemokine-1, a Novel Structural Homologue of Macrophage Inflammatory Protein-1α with a Th2-Associated Expression Pattern

1998 • 216 citations

Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors

2002 • 211 citations

Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

1998 • 203 citations

The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.

1996 • 202 citations

The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells

2003 • 199 citations

Human neutrophils secrete vascular endothelial growth factor

1997 • 193 citations

Vascular leukocytes contribute to tumor vascularization

2004 • 187 citations

Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats

1999 • 186 citations

Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors

2005 • 155 citations

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

1998 • 151 citations

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): Receptor biology, signal transduction, and neutrophil activation

1992 • 138 citations

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells.

1982 • 135 citations

Endothelium-Microenvironment Interactions in the Developing Embryo and in the Adult

2007 • 129 citations

The AVIT protein family

2003 • 121 citations

Non‐steroidal anti‐inflammatory drugs for the prevention and treatment of cancer

2005 • 113 citations

Eotaxin-2 Generation Is Differentially Regulated by Lipopolysaccharide and IL-4 in Monocytes and Macrophages

2002 • 103 citations

Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers

1999 • 97 citations

Innate immunity Innate pathways that control acquired immunity

1997 • 88 citations

Vascular remodeling and clinical resistance to antiangiogenic cancer therapy

2004 • 86 citations

Antiangiogenic Agents: an Update on Small Molecule VEGFR Inhibitors

2007 • 82 citations

A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance

2002 • 66 citations

Antiangiogenic Therapy for Cancer: An Update

2007 • 66 citations

PSEUDOEXONS AND REGULATORY ELEMENTS IN THE GENOMIC SEQUENCE OF THE β-CHEMOKINE, ALTERNATIVE MACROPHAGE ACTIVATION-ASSOCIATED CC-CHEMOKINE (AMAC)-1

2000 • 32 citations

Secretion of Monocyte Chemoattractant Protein-1 (MCP-1) by Human Mononuclear Phagocytes

1993 • 25 citations

The Immune Response

2001 • 21 citations

Do autochthonous tumors interfere with effector T cell responses?

2007 • 17 citations