Non‐steroidal anti‐inflammatory drugs for the prevention and treatment of cancer

The Hallmarks of Cancer

2000 • 27,569 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

2000 • 4,048 citations

Cancer Statistics, 2003

2003 • 3,302 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

2005 • 2,476 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

2005 • 2,039 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors

2001 • 1,716 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

2003 • 1,393 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer

2003 • 1,124 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery

2005 • 1,095 citations

Coxibs and Cardiovascular Disease

2004 • 897 citations

Proliferative Inflammatory Atrophy of the Prostate

1999 • 868 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.

2002 • 786 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

Failing the Public Health — Rofecoxib, Merck, and the FDA

2004 • 598 citations

Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults

2004 • 512 citations

Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer

2001 • 510 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin

1998 • 506 citations

Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis

1993 • 494 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis

2000 • 474 citations

Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo.

2002 • 444 citations

Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.

2001 • 410 citations

Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy

2004 • 386 citations

Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

Celecoxib Induces Apoptosis by Inhibiting 3-Phosphoinositide-dependent Protein Kinase-1 Activity in the Human Colon Cancer HT-29 Cell Line

2002 • 297 citations

Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.

1999 • 292 citations

Association of Frequency and Duration of Aspirin Use and Hormone Receptor Status With Breast Cancer Risk

2004 • 274 citations

Breast cancer and NSAID use: a meta-analysis

2001 • 268 citations

COX-2 inhibition and colorectal cancer

2004 • 268 citations

Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.

2001 • 267 citations

Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats.

2000 • 263 citations

Aspirin triggers antiinflammatory 15-epi-lipoxin A ₄ and inhibits thromboxane in a randomized human trial

2004 • 251 citations

The role of COX-2 inhibition in breast cancer treatment and prevention

2004 • 226 citations

Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer.

2002 • 222 citations

Non-steroidal anti-inflammatory drugs and bladder cancer prevention

2000 • 214 citations

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, EICOSANOIDS, AND COLORECTAL CANCER PREVENTION

1996 • 212 citations

Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11.

2002 • 198 citations

Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E ₂ /EP2 receptor pathway

2000 • 186 citations

Association of Malignancy With Diseases Causing Interstitial Pulmonary Changes

2002 • 182 citations

Carcinogen substrate specificity of human COX-1 and COX-2

2001 • 165 citations

E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse.

2000 • 162 citations

Aromatase and COX-2 expression in human breast cancers

2001 • 146 citations

A Population-Based Study of Daily Nonsteroidal Anti-inflammatory Drug Use and Prostate Cancer

2002 • 146 citations

Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance

2002 • 145 citations

Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors.

2002 • 141 citations

Cisplatin versus cisplatin combined with piroxicam in a canine model of human invasive urinary bladder cancer

2000 • 134 citations

COX-2 inhibition and lung cancer

2004 • 134 citations

Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis

1999 • 132 citations

Regulation by PGE₂ of the production of interleukin‐6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts

2002 • 128 citations

Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers

2002 • 126 citations

Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder

2001 • 125 citations

Alterations in Lipoxygenase and Cyclooxygenase-2 Catalytic Activity and mRNA Expression in Prostate Carcinoma

2001 • 108 citations

Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US.

2002 • 104 citations

Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes

2001 • 98 citations

Aspirin use in relation to risk of prostate cancer.

2002 • 97 citations

Cyclooxygenase-2 is Highly Expressed in Carcinoma in Situ and T1 Transitional Cell Carcinoma of the Bladder

2003 • 88 citations

Risk of breast cancer among users of aspirin and other anti-inflammatory drugs

2004 • 87 citations

Angiogenesis as a predictor of clinicaloutcome in cancer patients

2000 • 86 citations

Case-Control Study of Use of Nonsteroidal Antiinflammatory Drugs and Glioblastoma Multiforme

2004 • 82 citations

Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs

2003 • 81 citations

Targeting Angiogenic Processes by Combination Rofecoxib and Ionizing Radiation

2001 • 79 citations

Aspirin and the Risk of Hodgkin's Lymphoma in a Population-Based Case-Control Study

2004 • 76 citations

Association of aspirin and other non‐steroidal anti‐inflammatory drug use with incidence of non‐hodgkin lymphoma

2003 • 66 citations

Effect of Nonsteroidal Anti-Inflammatory Agents and Finasteride on Prostate Cancer Risk

2002 • 64 citations

AN OVERVIEW OF THE TREATMENT OF SUPERFICIAL BLADDER CANCER

2000 • 57 citations

COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer

2004 • 56 citations

NITRIC OXIDE DONATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS INDUCE APOPTOSIS IN HUMAN PROSTATE CANCER CELL SYSTEMS AND HUMAN PROSTATIC STROMA VIA CASPASE-3

2004 • 56 citations

Overexpression of cyclooxygenase-2 in non-small cell lung cancer

2003 • 56 citations

EXPRESSION OF CYCLOOXYGENASE-2 IN PATIENTS WITH BLADDER CARCINOMA

2001 • 42 citations

Synergistic Cytotoxicity and Apoptosis of JTE-522, a Selective Cyclooxygenase-2 Inhibitor, and 5-fluorouracil Against Bladder Cancer

2002 • 34 citations

Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines.

2001 • 29 citations

COX-2 inhibition in upper aerodigestive tract tumors

2004 • 23 citations

Intravesical therapy for superficial bladder cancer.

2000 • 18 citations

Intravesical Therapy for Superficial Bladder Cancer

2000 • 12 citations

Prospective pilot study of the preoperative use of celecoxcib and FEC for the treatment of locally advanced breast cancer

2003 • 7 citations