The transforming growth factor-βbgr/SMAD signaling pathway is present and functional in human mesangial cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Transforming growth factor beta

2011 • 1,990 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

SMADs: mediators and regulators of TGF-β signaling

1998 • 476 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Expression of transforming growth factor-β isoforms in human glomerular diseases

1996 • 424 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1999 • 388 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Mechanism of TGFβ receptor inhibition by FKBP12

1997 • 342 citations

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-β

1996 • 312 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys.

1993 • 249 citations

Role of Transforming Growth Factor- in Tissue Injury and Repair

1997 • 237 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Glomerular matrix accumulation is linked to inhibition of the plasmin protease system

1992 • 189 citations

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells

1998 • 179 citations

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene ( COL 7A1 ) promoter by transforming growth factor β

1998 • 178 citations

Sp1 Is Required for the Early Response of α2(I) Collagen to Transforming Growth Factor-β1

1997 • 175 citations

Induction of Smad6 mRNA by Bone Morphogenetic Proteins

1998 • 168 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

1990 • 127 citations

PDGF and TGF-β contribute to the natural course of human IgA glomerulonephritis

1995 • 122 citations

Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β

1998 • 118 citations

Abrogation of Smad3 and Smad2 or of Smad4 Gene Expression Positively Regulates Murine Embryonic Lung Branching Morphogenesis in Culture

1998 • 93 citations

Increased expression of extracellular matrix proteins and decreased expression of matrix proteases after serial passage of glomerular mesangial cells

1996 • 62 citations

Matrix protein synthesis by glomerular mesangial cells in culture: Effects of transforming growth factor β (TGFβ) and platelet‐derived growth factor (PDGF) on fibronectin and collagen type IV mRNA

1995 • 56 citations

Immunologic Renal Disease

1997 • 49 citations

Serine/threonine kinase receptors and ligands

1997 • 47 citations

Extracellular matrix production regulation by TGF-beta in corneal endothelial cells.

1998 • 38 citations

Role of angiotensin II in extracellular matrix and transforming growth factor-β1 expression in hypertensive rats

1994 • 37 citations

The Effect of Transforming Growth Factor β1 on Mesangial Cell Fibronectin Synthesis: Increased Incorporation into the Extracellular Matrix and Reduced pI but No Effect on Alternative Splicing

1993 • 33 citations

Role for Transforming Growth Factor β in Thromboxane-Induced Increases in Mesangial Cell Fibronectin Synthesis

1995 • 25 citations

Focal Segmental Glomerulosclerosis

2018 • 20 citations