Endothelial Apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

1998 • 2,263 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

1998 • 1,860 citations

Primary Pulmonary Hypertension

1997 • 1,748 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 1,666 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases

1997 • 1,334 citations

An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension

1992 • 1,180 citations

Constitutive Expression of phVEGF ₁₆₅ After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

1998 • 1,109 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries.

1990 • 844 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Apoptosis

1998 • 806 citations

The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

1997 • 797 citations

Superoxide in Apoptosis

1998 • 773 citations

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension

1998 • 771 citations

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

1995 • 770 citations

Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.

1996 • 689 citations

Circulating Activated Endothelial Cells in Sickle Cell Anemia

1997 • 653 citations

Apoptotic Vascular Endothelial Cells Become Procoagulant

1997 • 612 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry.

1989 • 463 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Cardiac Allograft Vasculopathy

1997 • 439 citations

Apoptosis and Related Proteins in Different Stages of Human Atherosclerotic Plaques

1998 • 432 citations

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

1999 • 418 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

1997 • 368 citations

Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.

1996 • 360 citations

Maximizing oxygen delivery in critically ill patients

1996 • 357 citations

Elevated Circulating Levels of C-C Chemokines in Patients With Congestive Heart Failure

1998 • 357 citations

Elevation of Circulating and Ventricular Adrenomedullin in Human Congestive Heart Failure

1995 • 356 citations

Vasoactive Substances Regulate Vascular Smooth Muscle Cell Apoptosis

1996 • 345 citations

Intracellular Pool of Vascular Endothelial Growth Factor in Human Neutrophils

1997 • 344 citations

High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells

1995 • 342 citations

Apoptosis in lymphoid and parenchymal cells during sepsis

1997 • 335 citations

ENDOTHELIAL CELL AND HEPATOCYTE DEATHS OCCUR BY APOPTOSIS AFTER ISCHEMIA-REPERFUSION INJURY IN THE RAT LIVER1,2

1999 • 333 citations

Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.

1997 • 331 citations

Shear stress inhibits apoptosis of human endothelial cells

1996 • 329 citations

Cold‐induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species

1999 • 321 citations

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

1999 • 312 citations

HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study.

1997 • 303 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

Immunoreactive adrenomedullin in human plasma

1994 • 286 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis.

1996 • 258 citations

Inhaled prostacyclin (PGI2) versus inhaled nitric oxide in adult respiratory distress syndrome.

1996 • 251 citations

Morphology of the endothelium over atherosclerotic plaques in human coronary arteries.

1988 • 243 citations

Serum albumin is a specific inhibitor of apoptosis in human endothelial cells

1996 • 240 citations

Internalization ofStaphylococcus aureusby Endothelial Cells Induces Apoptosis

1998 • 234 citations

Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells

1998 • 231 citations

Vascular Endothelial Growth Factor Inhibits Endothelial Cell Apoptosis Induced by Tumor Necrosis Factor-α: Balance Between Growth and Death Signals

1997 • 221 citations

Adrenomedullin as an Autocrine/Paracrine Apoptosis Survival Factor for Rat Endothelial Cells*

1997 • 221 citations

Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results

1998 • 220 citations

Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation.

1994 • 219 citations

Neurohumoral Prediction of Benefit From Carvedilol in Ischemic Left Ventricular Dysfunction

1999 • 217 citations

Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)

1998 • 216 citations

Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.

1994 • 207 citations

Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin

1995 • 207 citations

Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.

1991 • 206 citations

Elevated Circulating E-Selectin, Intercellular Adhesion Molecule 1, and von Willebrand Factor in Patients with Severe Infection

1998 • 205 citations

HDL and ApoA Prevent Cell Death of Endothelial Cells Induced by Oxidized LDL

1997 • 202 citations

Microvascular function and rheologic changes in hyperdynamic sepsis

1995 • 202 citations

The Effects of Intravenous Antioxidants in Patients With Septic Shock

1997 • 195 citations

2-Methoxyestradiol, an Endogenous Estrogen Metabolite, Induces Apoptosis in Endothelial Cells and Inhibits Angiogenesis: Possible Role for Stress-Activated Protein Kinase Signaling Pathway and Fas Expression

1997 • 193 citations

Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax

1996 • 185 citations

Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.

1996 • 184 citations

Endothelin-1 as an Autocrine/Paracrine Apoptosis Survival Factor for Endothelial Cells

1997 • 183 citations

Tenascin-C Is Induced With Progressive Pulmonary Vascular Disease in Rats and Is Functionally Related to Increased Smooth Muscle Cell Proliferation

1996 • 183 citations

Bacterial Lipopolysaccharide Disrupts Endothelial Monolayer Integrity and Survival Signaling Events through Caspase Cleavage of Adherens Junction Proteins

1998 • 183 citations

Human neutrophils produce high levels of the interleukin 1 receptor antagonist in response to granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

1992 • 179 citations

Hurst's the Heart, Arteries and Veins

1998 • 173 citations

Thrombotic Thrombocytopenic Purpura and Sporadic Hemolytic-Uremic Syndrome Plasmas Induce Apoptosis in Restricted Lineages of Human Microvascular Endothelial Cells

1997 • 172 citations

Regulation of Adrenomedullin Production in Rat Endothelial Cells¹

1998 • 170 citations

Continuous Infusion of Prostacyclin Normalizes Plasma Markers of Endothelial Cell Injury and Platelet Aggregation in Primary Pulmonary Hypertension

1997 • 166 citations

Antinuclear antibodies in primary pulmonary hypertension

1986 • 163 citations

Cytokine profiles of cultured microvascular endothelial cells from the human intestine

1998 • 160 citations

Increased secretion of tumor necrosis factor-alpha and interferon-gamma by mononuclear leukocytes in patients with ischemic heart disease. Relevance in superoxide anion generation.

1994 • 160 citations

Cyclosporin A Inhibits Apoptosis of Human Endothelial Cells by Preventing Release of Cytochrome C From Mitochondria

1998 • 158 citations

Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets

1985 • 157 citations

Phagocytosis of apoptotic bodies by liver endothelial cells

1995 • 157 citations

Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis

1997 • 153 citations

Human transplant coronary artery disease: pathological evidence for Fas-mediated apoptotic cytotoxicity in allograft arteriopathy.

1996 • 149 citations

Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome

1993 • 146 citations

Increased levels of the soluble adhesion molecule E-selectin in essential hypertension

1994 • 146 citations

Lipopolysaccharide Induces the Antiapoptotic Molecules, A1 and A20, in Microvascular Endothelial Cells

1998 • 142 citations

Oxidized LDLs Induce Massive Apoptosis of Cultured Human Endothelial Cells Through a Calcium-Dependent Pathway

1997 • 141 citations

Early evidence of endothelial vasodilator dysfunction at coronary branch points.

1990 • 140 citations

Circulating Factors as Markers and Mediators of Endothelial Cell Dysfunction in Preeclampsia

1998 • 139 citations

Endothelial Cell Apoptosis in Lipopolysaccharide–Induced Lung Injury in Mice

1998 • 137 citations

Superoxide Released to High Intra-arteriolar Pressure Reduces Nitric Oxide–Mediated Shear Stress– and Agonist-Induced Dilations

1998 • 134 citations

Apoptosis of Skeletal Muscle Myofibers and Interstitial Cells in Experimental Heart Failure

1998 • 129 citations

Cocaine opens the blood-brain barrier to HIV-1 invasion

1998 • 124 citations

Different patterns of IL‐1β secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7α‐, 7β‐hydroxycholesterol, or 7‐ketocholesterol

1998 • 122 citations

17β-Estradiol Inhibits Apoptosis of Endothelial Cells

1997 • 119 citations

Endothelial Activation and Development of Coronary Artery Disease in Transplanted Human Hearts

1997 • 114 citations

Hypoxia Increases the Susceptibility to Oxidant Stress and the Permeability of the Blood‐Brain Barrier Endothelial Cell Monolayer

1995 • 113 citations

Natriuretic Peptides and Nitric Oxide Induce Endothelial Apoptosis via a cGMP–Dependent Mechanism

1999 • 112 citations

Effect of recombinant human erythropoietin on endothelial cell apoptosis

1999 • 108 citations

Sickle Cell Anemia as a Possible State of Enhanced Anti-Apoptotic Tone: Survival Effect of Vascular Endothelial Growth Factor on Circulating and Unanchored Endothelial Cells

1999 • 107 citations

Circulating endothelial cells as a sign of vessel wall lesions.

1978 • 107 citations

Soluble ICAM-1 Activates Lung Macrophages and Enhances Lung Injury

1998 • 107 citations

Effects of hormone-replacement therapy on hemostatic factors, lipid factors, and endothelial function in women undergoing surgical menopause: Implications for prevention of atherosclerosis

1997 • 104 citations

Aspirin Increases Ferritin Synthesis in Endothelial Cells

1998 • 103 citations

Levels of Circulating Adhesion Molecules in Congestive Heart Failure and After Heart Transplantation

1998 • 102 citations

Mannitol at Clinical Concentrations Activates Multiple Signaling Pathways and Induces Apoptosis in Endothelial Cells

1998 • 102 citations

Renin Release, Saralasin and the Vasodilator-Beta-Blocker Drug Interaction in Man

1975 • 99 citations

Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species

1998 • 97 citations

Apoptosis Occurs in Endothelial Cells during Hypertension-Induced Microvascular Rarefaction

1997 • 90 citations

Increased plasma levels of adrenomedullin in patients with pulmonary hypertension

1999 • 89 citations

Induction of Endothelial Cell Apoptosis by Solid Tumor Cells

1998 • 86 citations

Production of Tumor Necrosis Factor-alpha and Interleukin-1beta by Human Cerebral Microvascular Endothelium after Percussive Trauma

1997 • 84 citations

Neurohormonal activity and left ventricular geometry in patients with essential arterial hypertension

1998 • 83 citations

Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor

1997 • 81 citations

Enhanced Endothelial Cell Apoptosis in Splenic Tissues of Patients With Thrombotic Thrombocytopenic Purpura

1999 • 75 citations

Mitochondrial Function Is Involved in LDL Oxidation Mediated by Human Cultured Endothelial Cells

1997 • 75 citations

Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1

1998 • 72 citations

Monocytes Stimulate Expression of the Bcl-2 Family Member, A1, in Endothelial Cells and Confer Protection Against Apoptosis

1999 • 72 citations

Aerosolized prostacyclin and inhaled nitric oxide in septic shock — different effects on splanchnic oxygenation?

1996 • 71 citations

Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells

1998 • 67 citations

Heat Shock Induces IκB-α and Prevents Stress-Induced Endothelial Cell Apoptosis

1997 • 65 citations

Strongly Enhanced Serum Levels of Vascular Endothelial Growth Factor (VEGF) after Poly-trauma and Burn

1998 • 65 citations

Localization of the apoptosis-inducing activity of lupus anticoagulant in an annexin V-binding antibody subset.

1998 • 64 citations

Endotoxin-induced vascular endothelial injury and repair

1976 • 64 citations

Coronary sinus sampling of cytokines after heart transplantation: Evidence for macrophage activation and interleukin-4 production within the graft

1993 • 62 citations

Endothelin-1 and Blood Pressure After Inhibition of Nitric Oxide Synthesis in Human Septic Shock

1999 • 62 citations

Activation of the Alternative Pathway of Human Complement by Apoptotic Human Umbilical Vein Endothelial Cells1

1994 • 60 citations

Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation

1998 • 60 citations

High prevalence of antiphospholipid antibodies in precapillary pulmonary hypertension.

1996 • 59 citations

Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells

1997 • 57 citations

Endothelial dysfunction early after heart transplantation. Assessment with intravascular ultrasound and Doppler.

1992 • 53 citations

ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release

1998 • 51 citations

Coronary artery apoptosis in experimental hypercholesterolemia

1999 • 48 citations

Integrins inhibit LPS-induced DNA strand breakage in cultured lung endothelial cells

1996 • 47 citations

Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelial-derived substances in the critically ill

1998 • 47 citations

Angiotensin converting enzyme expression in primary pulmonary hypertension.

1996 • 46 citations

Cyclosporine treatment reduces early atherosclerosis in the cholesterol-fed rabbit

1995 • 45 citations

Elevated neointimal endothelin-1 in transplantation-associated arteriosclerosis of renal allograft recipients

1998 • 43 citations

Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells

1997 • 43 citations

The effect of treatment of congestive heart failure on plasma atrial natriuretic peptide concentration: a longitudinal study.

1988 • 41 citations

A Circadian Variation Exists for Soluble Levels of Intercellular Adhesion Molecule-I and E-Selectin in Healthy Volunteers

1998 • 38 citations

Effect of Anti-DNA Autoantibodies on the Gene Expression of Interleukin 8, Transforming Growth Factor-β, and Nitric Oxide Synthase in Cultured Endothelial Cells

1997 • 38 citations

Human cardiac microvascular and macrovascular endothelial cells respond differently to oxidatively modified LDL

1998 • 33 citations

Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation

1995 • 33 citations

Detection and localization of tumor necrosis factor-α in WHHL rabbit arteries

1996 • 33 citations

Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy: Different stimuli for release before and after heart transplantation?

1999 • 30 citations

Hypertonicity Induces Injury to Cultured Human Endothelium: Attenuation by Glutamine

1997 • 29 citations

Non-Anticoagulant Heparin Increases Endothelial Nitric Oxide Synthase Activity: Role of Inhibitory Guanine Nucleotide Proteins

1998 • 29 citations

Steroid Sulfatase Activity in Human Lung Tissue and in Endothelial Pulmonary Cells in Culture*

1983 • 26 citations

Plasma adrenomedullin in cerebrovascular disease: a possible indicator of endothelial injury.

1997 • 23 citations

Paradoxic Pulmonary Vasoconstriction in Response to Acetylcholine in Patients With Primary Pulmonary Hypertension

1994 • 20 citations

Immunocytochemical Detection of Progesterone Receptors

1995 • 18 citations

Gender-specific protection from microvessel rarefaction in female hypertensive rats

1998 • 17 citations

Endothelial lesion in hypertension.

1989 • 17 citations

Polymorphonuclear Leukocytes Induce PDGF Release From IL-1β–Treated Endothelial Cells

1998 • 17 citations

Altered profile of endogeneous steroids in the urine of patients with prolactinoma

1998 • 16 citations

Vasotropic drugs--a survey based on a unifying concept of their mechanism of action.

1977 • 16 citations

Simulated glomerular hypertension promotes mesangial cell apoptosis and expression of cathepsin-B and SGP-2.

1998 • 16 citations

The effect of heparin on endothelial stability

1984 • 15 citations

Effect of high and low-dose aspirin on circulating endothelial cells.

1988 • 10 citations

The role of endothelium in the pathogenesis of vascular diseases.

1989 • 9 citations

Short-term effect of cyclosporine on circulating adrenomedullin after heart transplantation

1999 • 8 citations

Beneficial effect of PGI2 on circulating endothelial cells

1988 • 8 citations

Prevention of Exercise-Induced Endothelemia by Isradipine in Men with Angina pectoris

1994 • 6 citations

Captopril attenuates proteosynthesis in the aorta and decreases endothelaemia in rabbits with aortic insufficiency.

1998 • 5 citations

Neutrophil arachidonic acid level and adhesive capability are increased in essential hypertension

1998 • 4 citations

The effect of digoxin on endothelaemia in rats and its modification by a combination of troxerutin and coumarin.

1978 • 3 citations