The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

Statistical Methods for Rates and Proportions, 2nd ed

1981 • 3,735 citations

A Multiple Testing Procedure for Clinical Trials

1979 • 3,139 citations

Analysis of serial measurements in medical research.

1990 • 3,078 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Septic Shock in Humans

1990 • 1,170 citations

Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients

1994 • 952 citations

The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study

1995 • 345 citations

In VitroversusIn VivoComparison of Endotracheal Tube Airflow Resistance

1989 • 231 citations

An aid to data monitoring in long-term clinical trials

1982 • 200 citations

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

1983 • 183 citations

Effect of ibuprofen in patients with severe sepsis

1991 • 180 citations

PLASMA THROMBOXANE CONCENTRATIONS ARE RAISED IN PATIENTS DYING WITH SEPTIC SHOCK

1982 • 160 citations

Prostacyclin and Thromboxane A₂Formation Is Increased in Human Sepsis Syndrome: Effects of Cyclooxygenase Inhibition

1991 • 145 citations

Ibuprofen in canine endotoxin shock.

1982 • 131 citations

MODIFICATION, BY ASPIRIN AND INDOMETHACIN, OF THE HAEMODYNAMIC AND PROSTAGLANDIN RELEASING EFFECTS OF E. coli ENDOTOXIN IN THE DOG

1977 • 107 citations

Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.

1983 • 99 citations

Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS.

1994 • 89 citations

Inhibition of Prostaglandin Synthesis Restores Normal Hemodynamics in Canine Hyperdynamic Sepsis

1984 • 84 citations

The futility index. An approach to the cost-effective termination of randomized clinical trials

1985 • 83 citations

Elevated plasma 6-keto-prostaglandin F1α in patients in septic shock

1985 • 78 citations

Analgesic‐antipyretic drugs as antagonists of endotoxin shock in dogs

1962 • 77 citations

Receptive field organization of ganglion cells in the frog retina: contributions from cones, green rods and red rods.

1975 • 73 citations

Effects of acetylsalicylic acid on the canine response to endotoxin.

1967 • 69 citations

High-performance liquid chromatographic determination of ibuprofen and its major metabolites in biological fluids

1982 • 69 citations

EFFECT OF INDOMETHACIN ON ARTERIAL OXYGENATION IN CRITICALLY ILL PATIENTS WITH SEVERE BACTERIAL PNEUMONIA

1987 • 60 citations

Determinants of Cardiovascular Stability During Abdominal Aortic Aneurysmectomy (AAA)

1984 • 51 citations

Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism.

1993 • 49 citations

E. coli ENDOTOXIN SHOCK IN THE CAT; TREATMENT WITH INDOMETHACIN

1975 • 49 citations

Extraction of thromboxane B2 from urine using an immobilized antibody column for subsequent analysis by gas chromatography-mass spectrometry

1987 • 36 citations

Effects of Ibuprofen on Endotoxin-Induced Alveolitis: Biphasic Dose Response and Dissociation Between Inflammation and Hypoxemia

1986 • 36 citations

Effects of nonsteroidal anti-inflammatory drugs on renal function in septic dogs

1984 • 27 citations

Successful treatment of adult respiratory distress syndrome by histamine and prostaglandin blockade in a porcine Pseudomonas model.

1987 • 24 citations

Protection of myocardial function during endotoxin shock by ibuprofen

1984 • 20 citations

A critical comparison of the hematologic, cardiovascular, and pulmonary response to steroids and nonsteroidal anti-inflammatory drugs in a model of sepsis and adult respiratory distress syndrome.

1986 • 14 citations

The effect of ibuprofen on cardiac performance during abdominal aortic cross-clamping

1991 • 12 citations

ACID ASPIRATION INDUCED PULMONARY ARTERY PRESSURE RISE IS ATTENUATED BY HYPOXIA OR IBUPROFEN

1983 • 3 citations

SCLERODERMA & RAYNAUDS

1995 • 3 citations