Coordinate Regulation of Lipogenesis, the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins by Sterol Response Element Binding Protein 1

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.

1991 • 421 citations

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

1989 • 414 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

1993 • 396 citations

Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells.

1993 • 371 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

Apolipoprotein B: Structural and Metabolic Heterogeneity

1983 • 351 citations

Biochemistry of lipids and membranes

1986 • 332 citations

Sterol Regulation of Fatty Acid Synthase Promoter

1995 • 323 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

1993 • 300 citations

Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge.

1990 • 273 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene

1996 • 228 citations

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1994 • 218 citations

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

1990 • 192 citations

Intrahepatic assembly of very low density lipoproteins. Effect of fatty acids on triacylglycerol and apolipoprotein synthesis.

1982 • 179 citations

apoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE.

1994 • 174 citations

Cholesterol is required for secretion of very-low-density lipoprotein by rat liver

1989 • 160 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles

1995 • 148 citations

Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability.

1983 • 146 citations

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

1991 • 145 citations

Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation.

1992 • 144 citations

Head Group Specificity in the Requirement of Phosphatidylcholine Biosynthesis for Very Low Density Lipoprotein Secretion from Cultured Hepatocytes

1989 • 143 citations

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells.

1993 • 134 citations

Biosynthesis of Apolipoprotein B48-containing Lipoproteins

1996 • 129 citations

Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester.

1994 • 119 citations

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

1994 • 110 citations

Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting.

1985 • 110 citations

Molecular Cloning and Functional Analysis of the Promoter of the Human Squalene Synthase Gene

1995 • 108 citations

Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver.

1993 • 106 citations

Vitellogenin synthesis by the fat body of the mosquito Aedes aegypti

1973 • 98 citations

Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.

1992 • 97 citations

Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures.

1983 • 97 citations

Fasting decreases apolipoprotein B mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes: evidence that the total amount of apoB secreted is regulated post-transcriptionally

1990 • 94 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2.

1988 • 87 citations

Bile acid kinetics in relation to endogenous tryglyceride metabolism in various types of hyperlipoproteinemia.

1978 • 84 citations

In HepG2 Cells, Translocation, Not Degradation, Determines the Fate of the de Novo Synthesized Apolipoprotein B

1995 • 83 citations

Synthesis and secretion of apolipoprotein B from cultured liver cells

1995 • 82 citations

Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution.

1989 • 77 citations

Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine.

1993 • 60 citations

An expression system for human apolipoprotein B100 in a rat hepatoma cell line.

1990 • 54 citations

Structure, assembly and secretion of lipoproteins

1996 • 49 citations

Flounder intestinal absorptive cells have abundant gap junctions and may be coupled

1984 • 47 citations

Expression of 7 alpha-hydroxylase in non-hepatic cells results in liver phenotypic resistance of the low density lipoprotein receptor to cholesterol repression

1992 • 44 citations

The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B

1994 • 43 citations

Developmental coordinate expression of triacylglycerol and small molecular weight apoB synthesis and secretion by rat hepatocytes.

1988 • 43 citations

Studies on the induction and biosynthesis of vitellogenin, an oestrogen-induced glycolipophosphoprotein

1971 • 42 citations

Biogenesis of plasma lipoproteins in rat hepatoma McA-RH7777: Importance of diffusion-mediated events during cell growth

1989 • 30 citations

Female Steroid Hormones and Lipoprotein Synthesis in the Cockerel: Effects of Progesterone and Nafoxidine on the Estrogenic Stimulation of Very Low Density Lipoproteins (VLDL) Synthesis

1977 • 28 citations

Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase

1996 • 23 citations

Isoprenoids, sterols and bile acids

1996 • 18 citations