Biosynthesis of Apolipoprotein B48-containing Lipoproteins

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

1987 • 1,021 citations

Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia

1992 • 748 citations

Apolipoprotein B-48 Is the Product of a Messenger RNA with an Organ-Specific In-Frame Stop Codon

1987 • 746 citations

Complete protein sequence and identification of structural domains of human apolipoprotein B

1986 • 620 citations

Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein

1993 • 609 citations

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

1996 • 606 citations

The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.

1988 • 601 citations

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

1993 • 497 citations

[1] Introduction to the plasma lipoproteins

1986 • 420 citations

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

1989 • 414 citations

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

1990 • 369 citations

Subcellular localization of B apoprotein of plasma lipoproteins in rat liver.

1976 • 359 citations

Apolipoprotein B: Structural and Metabolic Heterogeneity

1983 • 351 citations

The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.

1993 • 286 citations

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

1995 • 286 citations

Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

1993 • 272 citations

The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas

1992 • 230 citations

The complete cDNA and amino acid sequence of human apolipoprotein B-100.

1986 • 227 citations

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1994 • 218 citations

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

1994 • 196 citations

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

1990 • 192 citations

Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells.

1986 • 190 citations

Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.

1988 • 186 citations

Evolutionary origins of apoB mRNA editing: Catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site

1995 • 180 citations

Studies on the Expression of Genes Encoding Apolipoproteins B100 and B48 and the Low Density Lipoprotein Receptor in Nonhuman Primates

1989 • 176 citations

apoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE.

1994 • 174 citations

The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.

1992 • 170 citations

Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

1991 • 169 citations

Apolipoprotein B: structure, biosynthesis and role in the lipoprotein assembly process

1987 • 164 citations

Microsomal Triglyceride Transfer Protein

1995 • 157 citations

Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.

1994 • 155 citations

Sequence requirements for the editing of apolipoprotein B mRNA.

1991 • 140 citations

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.

1994 • 137 citations

Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity

1995 • 133 citations

Apolipoprotein B synthesis by human liver and intestine in vitro.

1986 • 129 citations

Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.

1992 • 128 citations

The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.

1990 • 123 citations

apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Is a Novel RNA-binding Protein

1995 • 123 citations

Apolipoprotein B messenger RNA editing in the rat liver. Modulation by fasting and refeeding a high carbohydrate diet.

1990 • 114 citations

Cloning and mutagenesis of the rabbit ApoB mRNA editing protein. A zinc motif is essential for catalytic activity, and noncatalytic auxiliary factor(s) of the editing complex are widely distributed.

1994 • 113 citations

Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes

1992 • 111 citations

Lipid balance in HepG2 cells: active synthesis and impaired mobilization

1994 • 110 citations

RNA Editing: The alteration of protein coding sequences of RNA

1994 • 109 citations

Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.

1994 • 108 citations

Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins.

1993 • 107 citations

Fasting decreases apolipoprotein B mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes: evidence that the total amount of apoB secreted is regulated post-transcriptionally

1990 • 94 citations

Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editingin vitro

1992 • 93 citations

Apolipoprotein B mRNA editing is associated with UV crosslinking of proteins to the editing site.

1993 • 92 citations

Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum.

1995 • 92 citations

Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apolipoprotein B-100 and normal low density lipoprotein production.

1994 • 91 citations

Alternative mRNA Splicing and Differential Promoter Utilization Determine Tissue-specific Expression of the Apolipoprotein B mRNA-editing Protein (Apobec1) Gene in Mice.

1995 • 90 citations

Immunoelectron microscopy of low density lipoproteins yields a ribbon and bow model for the conformation of apolipoprotein B on the lipoprotein surface.

1995 • 90 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport

1993 • 88 citations

Apolipoprotein B mRNA editing: a new tier for the control of gene expression

1992 • 88 citations

Apolipoprotein B mRNA editing. Direct determination of the edited base and occurrence in non-apolipoprotein B-producing cell lines.

1990 • 87 citations

Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.

1993 • 86 citations

Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100.

1990 • 86 citations

RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitro coupled transcription editing.

1990 • 85 citations

Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.

1986 • 83 citations

Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apolipoprotein B mRNA editing enzyme: functional role in the modulation of apoB mRNA editing.

1995 • 83 citations

Cotranslocational insertion of apolipoprotein B into the inner leaflet of the endoplasmic reticulum

1991 • 81 citations

Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein

1994 • 79 citations

Apolipoprotein B mRNA sequences 3′ of the editing site are necessary and sufficient for editing and editosome assembly

1991 • 76 citations

Induction of RNA editing at heterologous sites by sequences in apolipoprotein B mRNA.

1993 • 72 citations

Brefeldin A Reversibly Inhibits the Assembly of ApoB Containing Lipoproteins in McA-RH7777 Cells

1995 • 72 citations

A 40 kilodalton rat liver nuclear protein binds specifically to apolipoprotein B mRNA around the RNA editing site

1990 • 68 citations

Effects of growth hormone on apolipoprotein-B (apoB) messenger ribonucleic acid editing, and apoB 48 and apoB 100 synthesis and secretion in the rat liver.

1992 • 63 citations

Expression and characterization of p27, the catalytic subunit of the apolipoprotein B mRNA editing enzyme.

1994 • 59 citations

Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain.

1994 • 51 citations

The Mechanism for Apo-B mRNA Editing Is Deamination

1993 • 49 citations

Biosynthesis of lipoprotein: location of nascent apoAI and apoB in the rough endoplasmic reticulum of chicken hepatocytes

1992 • 48 citations

Regulation of the expression of the H+-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae

1994 • 44 citations

Description of two different patients with abetalipoproteinemia: synthesis of a normal-sized apolipoprotein B-48 in intestinal organ culture.

1990 • 40 citations

Identification of a neutral lipid core in a transiently expressed and secreted lipoprotein containing an apoB-48-like apolipoprotein.

1992 • 14 citations