Rat hepatoma L35 cells, a liver-differentiated cell line, display resistance to bile acid repression of cholesterol 7 alpha-hydroxylase

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Functional specialization of different hepatocyte populations

1989 • 646 citations

Transcriptional control in the production of liver-specific mRNAs

1981 • 593 citations

Cholesterol 7α-hydroxylase

1977 • 504 citations

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

1991 • 479 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

Dynamics of the Enterohepatic Circulation of Bile Acids

1974 • 223 citations

Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat

1991 • 194 citations

Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.

1989 • 159 citations

Regulation of Hepatic 7α-Hydroxylase Expression and Response to Dietary Cholesterol in the Rat and Hamster

1995 • 149 citations

Hepatocyte heterogeneity: The coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation

1989 • 148 citations

Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability.

1983 • 146 citations

Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter

1994 • 134 citations

[53] Lactic dehydrogenases (crystalline)

1966 • 128 citations

Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures.

1992 • 124 citations

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport

1982 • 115 citations

Regulation of hepatic sterol metabolism in the rat. Parallel regulation of activity and mRNA for 7 alpha-hydroxylase but not 3-hydroxy-3-methylglutaryl-coenzyme A reductase or low density lipoprotein receptor.

1992 • 114 citations

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α‐hydroxylase

1990 • 114 citations

Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats

1991 • 111 citations

Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription

1995 • 108 citations

Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11–q12

1992 • 106 citations

Rat‐Liver Cholesterol 7α‐Hydroxylase

1975 • 100 citations

Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.

1984 • 99 citations

[98a] Phosphoglucose isomerase

1966 • 92 citations

Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids.

1983 • 88 citations

Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes

1993 • 87 citations

Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice

1993 • 84 citations

Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7α-hydroxylase in rats with biliary fistulas

1995 • 71 citations

Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase

1994 • 71 citations

Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase

1989 • 70 citations

Effect of biliary obstruction on formation and metabolism of bile acids in rat

1973 • 69 citations

Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes

1994 • 65 citations

Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes.

1985 • 64 citations

Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes.

1995 • 63 citations

The role of glucocorticoids in the regulation of the diurnal rhythm of hepatic β-hydroxy-β-methylglutaryl-coenzyme A reductase and cholesterol 7α-hydroxylase

1976 • 62 citations

Structure of the rat gene encoding cholesterol 7.alpha.-hydroxylase

1990 • 61 citations

Function and Regulation of Hydroxylases Involved in the Bile Acid Biosynthesis Pathways

1992 • 55 citations

Effects of Bile Acids and Steroid/Thyroid Hormones on the Expression of Cholesterol 7α-Hydroxylase mRNA and the CYP7 Gene in HepG2 Cells

1994 • 51 citations

Genomic Cloning, Sequencing, and Analysis of the Hamster Cholesterol 7α-Hydroxylase Gene (CYP7)

1993 • 51 citations

Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits

1993 • 51 citations

Heterogeneity of rat liver parenchyma in cholesterol 7α-hydroxylase and bile acid synthesis

1991 • 49 citations

Cholesterol 7α-hydroxylase of rat liver: An insulin sensitive enzyme

1984 • 48 citations

Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat

1993 • 44 citations

Examination of bile acid negative feedback regulation in rats.

1988 • 42 citations

Synchronization of hepatic cholesterol synthesis, cholesterol and bile acid content, fatty acid synthesis and plasma free fatty acid levels in the fed and fasted rat

1973 • 35 citations

Structure of the Mouse Cholesterol 7α-Hydroxylase Gene

1994 • 33 citations

Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol.

1991 • 31 citations

Structure of the gene encoding human liver cholesterol 7α-hydroxylase

1993 • 30 citations

The effect of portal blood bile salt concentrations on bile salt synthesis in rat liver

1981 • 28 citations

Feedback inhibition of bile acid synthesis in cultured pig hepatocytes

1988 • 21 citations

Structural Aspects of Bile Acids Involved in the Regulation of Cholesterol 7α‐Hydroxylase and Sterol 27‐Hydroxylase

1995 • 20 citations

Regulation of the Major Histocompatibility Complex Class I mRNA Expression by Bile Acids in Cultured Human Hepatoma Cells

1995 • 18 citations

Regulation of β-actin gene transcription by insulin and phorbol esters

1992 • 18 citations

The effect of variations in lipid composition of high-density lipoprotein on its interaction with receptors on human fibroblasts

1987 • 17 citations

Inhibition of procoagulant activity of human monocytes by chenodeoxycholic acid: Involvement of protein kinase C

1994 • 11 citations

Partial Cloning of cDNA for Hamster Liver Cholesterol 7.ALPHA.-Hydroxylase.

1993 • 7 citations

Effect of Insulin on Hepatic Bile Secretion during Normoglycaemia and Hyperglycaemia

1991 • 6 citations