Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles

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The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

NHLBI funding policies. Enhancing stability, predictability, and cost control.

1994 • 765 citations

Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia

1992 • 748 citations

Protein disulphide isomerase: building bridges in protein folding

1994 • 718 citations

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin

1985 • 622 citations

The retention signal for soluble proteins of the endoplasmic reticulum

1990 • 531 citations

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

1993 • 497 citations

PHOSPHOLIPID TRANSFER PROTEINS

1991 • 445 citations

Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.

1987 • 420 citations

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

1990 • 369 citations

Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds.

1994 • 268 citations

Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein

1993 • 240 citations

Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion

1994 • 219 citations

Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells.

1994 • 218 citations

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

1995 • 198 citations

Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer protein

1991 • 192 citations

Secretion of lipids, apolipoproteins, and lipoproteins by human hepatoma cell line, HepG2: effects of oleic acid and insulin

1987 • 178 citations

apoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE.

1994 • 174 citations

Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.

1991 • 169 citations

Microsomal Triglyceride Transfer Protein

1995 • 157 citations

Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells.

1994 • 155 citations

Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in Spodoptera frugiperda insect cells.

1992 • 152 citations

Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally

1990 • 151 citations

Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation.

1992 • 144 citations

Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.

1992 • 128 citations

Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators.

1994 • 128 citations

Purification and characterization of microsomal triglyceride and cholesteryl ester transfer protein from bovine liver microsomes

1985 • 119 citations

Pause transfer: A topogenic sequence in apolipoprotein B mediates stopping and restarting of translocation

1992 • 116 citations

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

1994 • 110 citations

Assembly of rat hepatic very low density lipoproteins in the endoplasmic reticulum.

1993 • 97 citations

Lipid transport processes in eukaryotic cells

1994 • 94 citations

Structural properties of the microsomal triglyceride-transfer protein complex

1991 • 92 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport

1993 • 88 citations

Identification of Two Classes of Lipid Molecule Binding Sites on the Microsomal Triglyceride Transfer Protein

1994 • 49 citations

Human microsomal triglyceride transfer protein large subunit gene structure

1994 • 44 citations

The photosynthetic apparatus: Molecular biology and operation

1992 • 6 citations