Remodeling of the Mammary Microenvironment after Lactation Promotes Breast Tumor Cell Metastasis

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

2002 • 15,184 citations

Inflammation and cancer

2002 • 14,174 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

Putting tumours in context

2001 • 2,145 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

Reconstruction of functionally normal and malignant human breast tissues in mice

2004 • 777 citations

Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.

1988 • 703 citations

A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections.

1985 • 615 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Context, tissue plasticity, and cancer

2005 • 470 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

The stroma as a crucial target in rat mammary gland carcinogenesis

2004 • 402 citations

The influence of the microenvironment on the malignant phenotype

2000 • 398 citations

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

2003 • 364 citations

Reproductive Risk Factors in a Prospective Study of Breast Cancer: The Nurses' Health Study

1994 • 360 citations

Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

2003 • 328 citations

Breast cancer risk by age at birth, time since birth and time intervals between births: exploring interaction effects

2004 • 309 citations

Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance

1999 • 274 citations

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.

1990 • 249 citations

Context, tissue plasticity, and cancerAre tumor stem cells also regulated by the microenvironment?

2005 • 248 citations

Influence of pregnancy on the outcome of breast cancer: A case-control study

1997 • 246 citations

Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel

1991 • 216 citations

Human breast carcinoma desmoplasia is PDGF initiated

2000 • 214 citations

Stromelysin-1 Regulates Adipogenesis during Mammary Gland Involution

2001 • 199 citations

Pathological and molecular mechanisms of prostate carcinogenesis: Implications for diagnosis, detection, prevention, and treatment

2003 • 189 citations

Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

2002 • 175 citations

Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

1998 • 152 citations

Mammary ECM composition and function are altered by reproductive state

2004 • 142 citations

VEGF-A164/165 and PlGF Roles in Angiogenesis and Arteriogenesis

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Matrix revolutions: ‘tails’ of basement-membrane components with angiostatic functions

2004 • 133 citations

A developmental atlas of rat mammary gland histology.

2000 • 131 citations

Estrous cycle regulation of mammary epithelial cell proliferation, differentiation, and death in the Sprague-Dawley rat: a model for investigating the role of estrous cycling in mammary carcinogenesis.

2000 • 128 citations

Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion.

2000 • 118 citations

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

1994 • 117 citations

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-κB by Suppressing Activation of I-κB α Kinase in Human Non-Small Cell Lung Carcinoma

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The relation of reproductive factors to mortality from breast cancer.

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Multistep tumorigenesis and the microenvironment

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Reproductive History and Mortality After Breast Cancer Diagnosis

2004 • 99 citations

Characterization of epithelial phenotypes in mortal and immortal human breast cells

1992 • 97 citations

Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling

2000 • 87 citations

Do inflammatory cells participate in mammary gland involution?

2002 • 84 citations

Worse Survival in Breast Cancer Among Women with Recent Childbirth: Results from a Swedish Population-Based Register Study

2003 • 84 citations

Expression of Matrix Metalloprotease-2-Cleaved Laminin-5 in Breast Remodeling Stimulated by Sex Steroids

1999 • 77 citations

Presence of the Acute Phase Protein, Bikunin, in the Endometrium of Gilts During Estrous Cycle and Early Pregnancy1

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ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells

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Growth and metastasis of human breast carcinomas with Matrigel in athymic mice

1993 • 70 citations

Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis.

1996 • 67 citations

Prognostic influence of pregnancy before, around, and after diagnosis of breast cancer

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The Relation of Reproductive Factors to Mortality From Breast Cancer

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Malignant transformation of NIH‐3T3 cells after subcutaneous co‐injection with a reconstituted basement membrane (matrigel)

1992 • 53 citations

Tumour-stromal interactions Reciprocal regulation of extracellular matrix proteins and ovarian steroid activity in the mammary gland

2001 • 50 citations

The UroVysion fluorescence in situ hybridization assay is an effective tool for monitoring recurrence of bladder cancer

2004 • 49 citations

Inability of Overexpressed des(1–3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules*

2001 • 32 citations

Programmed cell death and mammary neoplasia

1996 • 28 citations

Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling?

1992 • 22 citations

Loss of epithelial differentiation markers and acquisition of vimentin expression after xenograft with laminin-1 enhance migratory and invasive abilities of human colon cancer cells LoVo C5

1998 • 11 citations