Programmed cell death and mammary neoplasia

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Risk Factors for Breast Cancer in Women with Proliferative Breast Disease

1985 • 1,817 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase

1993 • 1,226 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

An Atlas of Subgross Pathology of the Human Breast With Special Reference to Possible Precancerous Lesions<xref ref-type="fn" rid="fn2">2</xref>

1975 • 761 citations

Breast Cancer

1992 • 695 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Breast cancer risk associated with proliferative breast disease and atypical hyperplasia

1993 • 526 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

A Prospective Study of Benign Breast Disease and the Risk of Breast Cancer

1992 • 491 citations

Induction and activation of tissue transglutaminase during programmed cell death

1987 • 467 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Cell death by apoptosis and its protective role against disease

1992 • 439 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Age at first birth, parity and risk of breast cancer: A meta‐analysis of 8 studies from the nordic countries

1990 • 287 citations

Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein.

1992 • 270 citations

Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous

1990 • 264 citations

Apoptosis induced by inhibition of intercellular contact.

1994 • 256 citations

DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.

1990 • 249 citations

Influence of age and parity on the development of the human breast

1992 • 232 citations

Age at any birth and breast cancer risk

1983 • 231 citations

A 25 kDa α₂‐microglobulin‐related protein is a component of the 125 kDa form of human gelatinase

1992 • 226 citations

Effect of Transforming Growth Factor-β¹on Proliferation and Death of Rat Prostatic Cells*

1990 • 218 citations

Distribution of myoepithelial cells and basement membrane proteins in the resting, pregnant, lactating, and involuting rat mammary gland.

1982 • 213 citations

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain.

1994 • 209 citations

LACTATION AND BREAST CANCER: EVIDENCE FOR A NEGATIVE ASSOCIATION IN PREMENOPAUSAL WOMEN

1985 • 205 citations

The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium.

1993 • 183 citations

A prospective study of benign breast disease and the risk of breast cancer

1992 • 178 citations

Death by suicide: one way to go in mammalian cellular development?

1991 • 167 citations

Biology of lactation.

1971 • 150 citations

EVIDENCE FOR A PROTECTIVE EFFECT OF LACTATION ON RISK OF BREAST CANCER IN YOUNG WOMEN

1986 • 150 citations

ORIGINAL CONTRIBUTIONS

1992 • 140 citations

Oncogenes and human cancer: cause or consequence?

1986 • 127 citations

Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast

1992 • 126 citations

Regulatory Mechanisms in Breast Cancer

1991 • 124 citations

Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk.

1993 • 108 citations

Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary gland

1980 • 106 citations

Apoptosis in the genesis and prevention of cancer.

1992 • 101 citations

Removal of basement membrane in the involuting breast.

1976 • 96 citations

Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells.

1988 • 93 citations

Studies on mammary gland involution

1968 • 90 citations

Induction of gene expression during involution of the lactating mammary gland of the rat

1994 • 80 citations

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse.

1987 • 79 citations

Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland.

1992 • 77 citations

Involution of the Mammary Gland

1978 • 76 citations

Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation

1994 • 74 citations

Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse

1994 • 64 citations

Expression of Matrilysin mRNA in Colorectal Adenomas and Its Induction by Truncated Fibronectin

1994 • 62 citations

The preneoplastic state in mouse mammary tumorigenesis

1988 • 50 citations

Protoneoplasia: The Molecular Biology of Murine Mammary Hyperplasia

1984 • 49 citations

Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein

1995 • 48 citations

Effect of Retinyl Acetate on the Incidence of Mammary Carcinomas and Hepatomas in Mice<xref ref-type="fn" rid="FN2">2</xref>

1980 • 46 citations

Electron Microscopy of Milk Secretion in the Mammary Gland of the C3H/Crgl Mouse. III. Cytomorphology of the Involuting Gland<xref ref-type="fn" rid="fn1">2</xref>

1963 • 37 citations

Stromal-epithelial interactions in normal and neoplastic mammary gland

1991 • 33 citations

Myoepithelium in involuting mammary glands of the rat.

1972 • 31 citations

Inhibition of Tumor Promotion by DL-α-Difluoromethylornithine, A Specific Irreversible Inhibitor of Ornithine Decarboxylase

1990 • 24 citations

H-ras induced transformation of mammary epithelium is favoured by increased oncogene expression or by inhibition of mammary regression.

1991 • 24 citations

Treatment with chemopreventive agents, difluoromethylornithine and retinyl acetate, results in altered mammary extracellular matrix

1995 • 20 citations

PROPERTIES OF THE ANTIHEMORRHAGIC VITAMIN (VITAMIN K)

1938 • 6 citations