The Wnt-1 proto-oncogene induces changes in morphology, gene expression, and growth factor responsiveness in PC12 cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Wnt genes

1992 • 799 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin

1988 • 653 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern

1986 • 630 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

Plakoglobin: A protein common to different kinds of intercellular adhering junctions

1986 • 508 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

1991 • 279 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

[18] PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation

1987 • 243 citations

Swaying is a mutant allele of the proto-oncogene Wnt-1

1991 • 242 citations

The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons

1988 • 239 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

The causal analysis of development in the past half century: a personal history

1992 • 214 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction

1992 • 178 citations

NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cells

1978 • 172 citations

Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.

1992 • 155 citations

Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

1988 • 153 citations

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway

1987 • 141 citations

NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells

1989 • 140 citations

The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

1992 • 138 citations

Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

1986 • 137 citations

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

1993 • 132 citations

Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos

1991 • 129 citations

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.

1992 • 128 citations

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.

1987 • 116 citations

Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line.

1992 • 109 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

Cell Adhesion In Morphogenesis

1987 • 108 citations

The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.

1987 • 91 citations

Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor

1980 • 85 citations

Identification of protein products encoded by the proto-oncogene int-1.

1987 • 80 citations

Isolation of cDNAs partially encoding four Xenopus - proteins and characterization of their transient expression during embryonic development

1991 • 77 citations

Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development

1989 • 73 citations

Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene

1989 • 70 citations

myc and E1A oncogenes alter the responses of PC12 cells to nerve growth factor and block differentiation.

1987 • 66 citations

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.

1991 • 60 citations

Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1 (int-1) oncogene in reconstituted mammary gland.

1992 • 58 citations

Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos

1992 • 51 citations

Role of endocrine, autocrine, and paracrine interactions in the development of mammary hyperplasia in Wnt-1 transgenic mice.

1992 • 51 citations

Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family.

1992 • 51 citations

Adenovirus 5 E1A proteins disrupt the neuronal phenotype and growth factor responsiveness of PC12 cells by a conserved region 1-dependent mechanism.

1993 • 48 citations

Two wnt genes in Caenorhabditis elegans.

1993 • 36 citations

Transient Expression of the Proto-Oncogene int-1 during Differentiation of P19 Embryonal Carcinoma Cells

1989 • 33 citations

The int-1 proto-oncogene is transcriptionally activated during neuroectodermal differentiation of P19 mouse embryonal carcinoma cells.

1989 • 32 citations

Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.

1989 • 25 citations

1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Resistant, Flat‐Cell PC12 Variants Having a Partial Loss of Transformed Phenotype

1990 • 17 citations

Differentiation of PC12 cells with nerve growth factor is associated with induction of transin synthesis and release

1992 • 16 citations