The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular cloning of sequences from wingless , a segment polarity gene in Drosophila : the spatial distribution of a transcript in embryos

1987 • 437 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

1990 • 374 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

1991 • 279 citations

Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos

1987 • 261 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact

1984 • 222 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse

1979 • 195 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

1990 • 188 citations

Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences

1988 • 157 citations

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

1987 • 145 citations

The int genes in mammary tumorigenesis and in normal development

1988 • 117 citations

Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity.

1987 • 116 citations

Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene

1989 • 70 citations

A role for adherons in neural retina cell adhesion.

1983 • 69 citations

Murine mammary tumor virus (MuMTV) infection of an epithelial cell line established from C57BL/6 mouse mammary glands

1978 • 68 citations

Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice

1987 • 47 citations

A helping hand from proteoglycans

1991 • 30 citations

Molecular and cellular interactions responsible for intrasegmental patterning during Drosophila embryogenesis.

1990 • 22 citations

Construction of a retroviral cDNA version of the int-l mammary oncogene and its expression in vitro

1986 • 19 citations

DNA Cloning‐A practical approach (vol. III)

1988 • 8 citations