Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

1984 • 538 citations

Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells

1989 • 389 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors.

1984 • 246 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates

1979 • 217 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresis.

1980 • 170 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain.

1986 • 162 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence

1986 • 142 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Epithelium-specific surface glycoprotein of Mr 34,000 is a widely distributed human carcinoma marker

1987 • 136 citations

Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.

1989 • 122 citations

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3).

1984 • 119 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

MONOCLONAL ANTI-Ia MURINE ALLOANTIBODIES CROSSREACTIVE WITH THE Ia-HOMOLOGUES OF OTHER MAMMALIAN SPECIES INCLUDING HUMANS1

1983 • 93 citations

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.

1984 • 90 citations

Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation.

1987 • 85 citations

Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus.

1986 • 69 citations

Ia antigens and associated invariant chain are induced simultaneously in lines of T-dependent mast cells by recombinant interferon-gamma.

1984 • 55 citations

The HLA-D-associated invariant chain binds palmitic acid at the cysteine adjacent to the membrane segment.

1986 • 49 citations

The human Ia-associated invariant chain is synthesized in Ia-negative B cell variants and is not expressed on the cell surface of both Ia-negative and Ia-positive parental cells.

1985 • 34 citations

Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells.

1987 • 31 citations

Cell surface expression of invariant gamma-chain of class II histocompatibility antigens in human skin.

1986 • 30 citations

MHC class II invariant chains in antigen processing and presentation

1989 • 28 citations

Xyloside inhibits synthesis of the class II-associated chondroitin sulfate proteoglycan and antigen presentation events.

1987 • 23 citations

The selective solubilization of different murine splenocyte membrane fractions with lubrol WX and triton X-100 distinguishes two forms of Ia antigens. A cell surface (alpha, beta) and an intracellular (alpha, Ii, beta).

1982 • 22 citations

Inhibition of proteoglycan synthesis eliminates the proteoglycan form of Ia-associated invariant chain and depresses antigen presentation.

1987 • 22 citations