The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Patterns of Amino Acids near Signal‐Sequence Cleavage Sites

1983 • 2,290 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles

1983 • 1,256 citations

Current Topics in Membranes and Transport

1970 • 1,240 citations

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

1975 • 1,175 citations

Transfer of Proteins Across Membranes

1981 • 894 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probes

1983 • 606 citations

Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.

1983 • 568 citations

Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

1984 • 538 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Primary structure of human transferrin receptor deduced from the mRNA sequence

1984 • 351 citations

Purification of microsomal signal peptidase as a complex.

1986 • 313 citations

Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane.

1977 • 286 citations

Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and β2-microglobulin

1979 • 274 citations

A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function.

1978 • 266 citations

Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity.

1977 • 259 citations

A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences.

1984 • 251 citations

An internal signal sequence: The asialoglycoprotein receptor membrane anchor

1986 • 209 citations

Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor.

1985 • 195 citations

Structural requirements of a membrane-spanning domain for protein anchoring and cell surface transport

1985 • 173 citations

cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.

1983 • 166 citations

NH2-terminal hydrophobic region of influenza virus neuraminidase provides the signal function in translocation.

1984 • 156 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

A stop transfer sequence confers predictable transmembrane orientation to a previously secreted protein in cell-free systems

1983 • 142 citations

The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.

1984 • 124 citations

Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence.

1984 • 124 citations

Analysis of signals for secretion in the staphylococcal protein A gene.

1985 • 100 citations

Chapter 4 Structural and Thermodynamic Aspects of the Transfer of Proteins into and across Membranes

1985 • 96 citations

Direct evidence for the transmembrane orientation of the hepatic glycoprotein receptors.

1984 • 84 citations

Substrate recognition by oligosaccharyl transferase. Inhibition of co-translational glycosylation by acceptor peptides.

1983 • 71 citations

Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus.

1986 • 69 citations

Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail.

1986 • 66 citations

Hen oviduct signal peptidase is an integral membrane protein.

1983 • 65 citations

Signal recognition particle-dependent insertion of coronavirus E1, an intracellular membrane glycoprotein.

1985 • 50 citations

Mutants of the membrane-binding region of Semliki Forest virus E2 protein. II. Topology and membrane binding.

1986 • 44 citations

In search of a function for the invariant chain associated with la antigens

1985 • 43 citations

Chapter 1 Application of the Signal Hypothesis to the Incorporation of Integral Membrane Proteins

1985 • 41 citations

Glycosylation and surface expression of the influenza virus neuraminidase requires the N-terminal hydrophobic region.

1984 • 40 citations

Pushing the signal hypothesis: what are the limits?

1985 • 37 citations