Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

1991 • 1,564 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

1989 • 984 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

Differential expression of myc family genes during murine development

1986 • 542 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.

1992 • 480 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

The expression pattern ofId4, a novel dominant negative helix-loop-helix protein, is distinct fromId1,1d2andId3

1994 • 274 citations

Inhibition of Myeloid Differentiation by the Helix-Loop-Helix Protein Id

1992 • 267 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Id2 Specifically Alters Regulation of the Cell Cycle by Tumor Suppressor Proteins

1996 • 242 citations

High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

1997 • 238 citations

Id proteins control growth induction in mammalian cells.

1994 • 229 citations

Regulation of G1 progression by E2A and Id helix-loop-helix proteins.

1994 • 199 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 • 151 citations

Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription

1992 • 139 citations

A human Id-like helix-loop-helix protein expressed during early development.

1992 • 138 citations

Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors

1997 • 129 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia.

1993 • 112 citations

Regulation of Id3 Cell Cycle Function by Cdk-2-Dependent Phosphorylation

1997 • 103 citations

Localization of E2A mRNA expression in developing and adult rat tissues.

1993 • 101 citations

Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.

1992 • 86 citations

Regulation of T cell receptor (TCR)‐β locus allelic exclusion and initiation of TCR‐α locus rearrangement in immature thymocytes by signaling through the CD3 complex

1995 • 73 citations

Selecting the T Cell Receptor Repertoire

1994 • 71 citations

T cell receptor variable gene usage in a specific cytotoxic T cell response. Primary structure of the antigen-MHC receptor of four hapten-specific cytotoxic T cell clones.

1987 • 68 citations

Id gene expression and its suppression by 1,25-dihydroxyvitamin D3 in rat osteoblastic osteosarcoma cells.

1992 • 64 citations

Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells

1986 • 55 citations

Asymmetric Redundancy in CD4 Silencer Function

1996 • 42 citations

Phosphorylation of Helix-Loop-Helix Proteins Id1, Id2 and Id3

1995 • 30 citations