Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

Flt3 ligand induces tumor regression and antitumor immune responses in vivo

1997 • 315 citations

Immunotherapy of cancer with dendritic-cell-based vaccines

1998 • 298 citations

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

1994 • 254 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 219 citations

Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer.

1999 • 211 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice

1997 • 193 citations

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

1996 • 150 citations

Heat shock proteins: the fountainhead of innate and adaptive immune responses

2000 • 134 citations

MHC imbalance and metastatic spread in Lewis lung carcinoma clones

1983 • 131 citations

Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model.

1997 • 117 citations

Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer

1997 • 62 citations

Antigen recognition by H-2-restricted cytolytic T lymphocytes: inhibition of cytolysis by anti-CDS monoclonal antibodies depends upon both concentration and primary sequence of peptide antigen

1988 • 35 citations

Curative Antitumor Immune Response Is Optimal with Tumor Irradiation Followed by Genetic Induction of Major Histocompatibility Complex Class I and Class II Molecules and Suppression of Ii Protein

2005 • 15 citations

Pregnancy induced mammary tumor specific effector cells are present long after parturition in a breast cancer model in rats

2000 • 6 citations