Mutagens in cooked foods

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

1975 • 7,413 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Dehydrated Foods, Chemistry of Browning Reactions in Model Systems

1953 • 1,837 citations

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

The origin of human cancers

1981 • 653 citations

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

1985 • 373 citations

Mutagenicities of smoke condensates and the charred surface of fish and meat

1977 • 354 citations

ENVIRONMENTAL MUTAGENS AND CARCINOGENS

1978 • 315 citations

A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene

1985 • 286 citations

Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products

1977 • 282 citations

Formation of Mutagens in Beef and Beef Extract During Cooking

1978 • 264 citations

Detection and chemical identification of natural bio-antimutagens

1985 • 252 citations

Benzo( a )pyrene and Other Polynuclear Hydrocarbons in Charcoal-Broiled Meat

1964 • 238 citations

Effects of temperature and time on mutagen formation in pan-fried hamburger

1979 • 237 citations

Mutagens, carcinogens, and tumor promoters in our daily food

1982 • 233 citations

Mutagenicities of quinoline and its derivatives

1977 • 213 citations

Environmental Carcinogens selected Methods of Analysis

1982 • 198 citations

Mutagenicity of flavone derivatives.

1977 • 193 citations

Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract

1984 • 180 citations

Carcinogenicity in Mice of Mutagenic Compounds from a Tryptophan Pyrolyzate

1981 • 178 citations

Mechanisms of heat damage in proteins

1970 • 155 citations

Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin

1978 • 154 citations

Potent novel mutagens produced by broiling fish under normal conditions.

1980 • 154 citations

Recent developments in studies of the maillard reaction

1981 • 148 citations

STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

1981 • 146 citations

Demonstration of mutagenicity of aniline and o-toluidine by norharman.

1977 • 144 citations

Creatinine and Maillard Reaction Products as Precursors of Mutagenic Compounds Formed in Fried Beef

1983 • 144 citations

Mutagenicities of protein pyrolysates

1977 • 142 citations

Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.

1978 • 139 citations

Anti-mutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate

1978 • 134 citations

Mutagens from the cooking of food

1981 • 130 citations

Carcinogenic activity of quinoline on rat liver.

1976 • 124 citations

Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose

1984 • 116 citations

Naturally Occurring Anticarcinogenic Substances in Foodstuffs

1985 • 114 citations

Mutagenic Factors in Cooked Foods

1979 • 112 citations

Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish

1980 • 109 citations

Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium TA98

1985 • 108 citations

Mutagenic activity of amino acid pyrolyzates in Salmonella typhimurium TA 98

1977 • 107 citations

Creatin(in)e and Maillard reaction products as precursors of mutagenic compounds: Effects of various amino acids

1983 • 105 citations

Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate.

1983 • 104 citations

Studies on natural desmutagens: Screening for vegetable and fruit factors active in inactivation of multagenic pyrolysis products from amino acids.

1978 • 104 citations

Purification and mass spectral characterization of bacterial mutagens from commercial beef extract.

1983 • 94 citations

Comparative genotoxic effects of the cooked-food-related mutagens Trp-P-2 and IQ in bacteria and cultured mammalian cells

1983 • 94 citations

Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates

1984 • 93 citations

STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH

1980 • 86 citations

The effect of temperature on the formation of mutagens in heated beef stock and cooked ground beef

1979 • 85 citations

Ultimate forms of mutagenic and carcinogenic heterocyclic amines produced by pyrolysis

1983 • 84 citations

Formation of mutagens in sugar-ammonia model systems

1979 • 83 citations

In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens

1984 • 82 citations

Effects of meat composition and cooking conditions on mutagen formation in fried ground beef

1983 • 82 citations

Human saliva inactivates mutagenicity of carcinogens

1981 • 81 citations

Mutagens from the cooking of food. II. Survey by Ames/Salmonella test of mutagen formation in the major protein-rich foods of the American diet

1982 • 81 citations

N-hydroxylation of carcinogenic and mutagenic aromatic amines.

1983 • 81 citations

Mechanism of activation of proximate mutagens in Ames' tester strains: The acetyl-CoA dependent enzyme in TA98 deficient in catalyzes DNA-binding as the cause of mutagenicity

1983 • 81 citations

Formation of mutagens in cooked foods. I. Beef

1979 • 80 citations

Fallacies of lifestyle cancer theories

1981 • 79 citations

Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef

1980 • 76 citations

Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes

1980 • 75 citations

Genetic toxicology : an agricultural perspective

1982 • 71 citations

Mutagenicity of products obtained free from cysteamine-glucose browning model systems

1980 • 69 citations

Quantification of 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) and 2-amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC)

1985 • 69 citations

Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reaction with DNA

1980 • 68 citations

Carcinogenic activity of 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan

1981 • 67 citations

Formation of 2-amino-3,7,8-trimethylimidazo[4,5-ƒ]quinoxaline, a new mutagen, by heating a mixture of creatinine, glucose and glycine

1984 • 67 citations

Chemical synthesis of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), a potent mutagen isolated from broiled fish.

1980 • 66 citations

Quinoline: Conversion to a Mutagen by Human and Rodent Liver2

1978 • 66 citations

Mixtures of polycyclic aromatic compounds inhibit mutagenesis in the Salmonella/microsome assay by inhibition of metabolic activation

1983 • 66 citations

Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.

1982 • 66 citations

Formation of mutagens in cooked foods V. The mutagen reducing effect of soy protein concentrates and antioxidants during frying of beef

1982 • 63 citations

Induction of sister-chromatid exchanges by mutagens from amino acid and protein pyrolysates

1980 • 62 citations

Modification of DNA with potent mutacarcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole isolated from a glutamic acid pyrolysate: structure of the modified nucleic acid base and initial chemical event caused by the mutagen

1982 • 61 citations

Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3′,2′-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole and its reaction with DNA

1980 • 60 citations

An XAD-2 resin method for efficient extraction of mutagens from fried ground beef

1982 • 59 citations

Qualitative and quantitative characterization of mutagens in commercial beef extract

1983 • 59 citations

Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole and 2-amino-dipyrido[1,2-a:3′,2′-d]imidazole, by purified cytochrome P-450

1981 • 58 citations

Clastogenic and Mutagenic Activities of Maillard Reaction Model Systems

1981 • 55 citations

A potent mutagen in broiled fish. Part 1. 2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline

1981 • 54 citations

Volatilization of mutagens from beef during cooking

1979 • 53 citations

Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a marker

1983 • 52 citations

High-pressure liquid chromatographic method for the analysis of 2-amino-3-methylimidazo[4,5-f]quinoline, a mutagen formed during the cooking of food

1983 • 51 citations

Effect of methyl substitution on mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline isolated from broiled sardine

1981 • 51 citations

Formation of mutagens in cooked foods. II. Foods with high starch content

1980 • 50 citations

Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes.

1980 • 49 citations

Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases

1983 • 46 citations

Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system

1980 • 44 citations

In vitro transformation of hamster embryo cells with tryptophan pyrolysis products.

1977 • 44 citations

Anti-mutagenic chalcones: Antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium

1983 • 44 citations

Purification and properties of a plant desmutagenic factor for the mutagenic principle of tryptophan pyrolysate.

1981 • 43 citations

Identification of a reactive metabolite of the mutagen, 2-amino-3-methylimidazolo(4,5-f)quinoline.

1981 • 43 citations

Isolation of 2-amino-3-methyl-imidazo-(4,5-f)quinoline as mutagen from the heated product of a mixture of creatine and proline.

1984 • 42 citations

Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA.

1981 • 39 citations

Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes

1982 • 39 citations

Species difference in N-hydroxylation of a tryptophan pyrolysis product in relation to mutagenic activation.

1981 • 38 citations

Mutagens from the cooking of food. III. Survey by Ames/Salmonella test of mutagen formation in secondary sources of cooked dietary protein

1982 • 37 citations

Isolation and structure determination of a mutagenic substance in L-lysine pyrolysate.

1978 • 37 citations

Antimutagenic action of cobaltous chloride on Trp-P-1-induced mutations in Salmonella typhimurium TA98 and TA1538

1982 • 36 citations

Enhancing effect of harman on mutagenicity in Salmonella

1977 • 36 citations

Mutagenicities of γ-carboline derivatives related to potent mutagens found in tryptophan pyrolysates

1980 • 35 citations

Fractionation of a mutagenic principle from broiled fish by high-pressure liquid chromatography

1979 • 35 citations

Isolation of mutagens from bacterial nutrients containing beef extract

1978 • 35 citations

Enhancement of binding of N-hydroxy-Trp-P-2 to DNA by seryl-tRNA synthetase

1981 • 34 citations

Covalent binding of N-hydroxy-Trp-P-2 to DNA by cytosolic proline-dependent system

1982 • 33 citations

Pyrolysis products from amino acids and protein: Highest mutagenicity requires cytochrome P ₁ -450

1979 • 32 citations

Identification and quantification of 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline (4,8-DiMeIQx) in beef extract

1985 • 32 citations

Genotoxicity of the food mutagen 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and analogs

1985 • 32 citations

There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.

1980 • 31 citations

Tobacco Carcinogenesis

1978 • 31 citations

Antimutagenic activity of browning reaction products

1982 • 31 citations

Seventy Years of the Maillard Reaction

1983 • 29 citations

Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products

1979 • 29 citations

Formation of mutagens in sugar-amino acid model systems

1983 • 29 citations

Mutagenecity of the browing mixtures by amino-carbonyl reactions on Salmonella typhimurium TA 100.

1980 • 29 citations

Mutagen production during pan-broiling compared with microwave irradiation of beef

1981 • 28 citations

Malignant transformation in vitro by tryptophan pyrolysis products.

1978 • 27 citations

Vegetables inhibit, in vivo, the mutagenicity of nitrite combined with nitrosable compounds

1983 • 27 citations

Actions of amino-β-carbolines on induction of sister-chromatid exchanges

1983 • 27 citations

Mutagenicity of Maillard browning products obtained from a starch-glycine model system

1981 • 26 citations

Activation of the mutagens of beef extract in vitro and in vivo

1980 • 26 citations

Induction of tumors in the forestomach and liver of mice by feeding 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ).

1985 • 25 citations

Lack of mutagens in deep-fat-fried foods obtained at the retail level

1982 • 25 citations

Damaging Effect of Dietary Components to Colon Epithelial Cells In Vivo: Effect of Mutagenic Heterocyclic Amines<xref ref-type="fn" rid="FN2">2</xref>

1984 • 25 citations

In vitro transformation of hamster embryo cells with a glutamic acid pyrolysis product

1979 • 25 citations

Formation of mutagens in cooked foods. IV. Effect of fat content in fried beef patties

1981 • 24 citations

Mutagenicity of products obtained from a maltol-ammonia browning model system

1981 • 24 citations

Analysis of mutagenic imidazo[4,5-f]quinolines and -quinoxalines (IQ compounds)

1985 • 24 citations

PURIFICATION AND PROPERTIES OF DESMUTAGENIC FACTOR FROM BROCCOLI (BRASSICA OLERANCEA VAR. ITALICA PLENCK) FOR MUTAGENIC PRINCIPLE OF TRYPTOPHAN PYROLYSATE

1982 • 23 citations

Formation of mutagens by heating creatine and glucose

1980 • 23 citations

Mutagenicity of some indoles and related compounds in the Ames test

1982 • 23 citations

Topography of RNA in the ribosome: Localization of the 3′‐end of the 23 S RNA on the surface of the 50 S ribosomal subunit by immune electron microscopy

1980 • 23 citations

Mutagen formation during the cooking of fish

1981 • 23 citations

Metabolic activation of 3-amino-5H-pyrido[4,3-b]indole, a highly mutagenic principle in tryptophan pyrolysate, by rat liver enzymes

1979 • 22 citations

Compounds produced by the reaction of 2-hydroxy-3-methyl-2-cyclopenten-1-one with ammonia and hydrogen sulfide

1980 • 22 citations

Immunological analysis of the roles of two major types of cytochrome P-450 in mutagenesis of compounds isolated from pyrolysates

1982 • 22 citations

Isolation of 2-amino-9H-pyrido[2,3-b]indole and 2-amino-3-methyl-9H-pyrido[2,3-b]indole as mutagens from pyrolysis product of tryptophan.

1979 • 21 citations

Rat liver microsome-mediated binding to DNA of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a potent mutagen isolated from tryptophan pyrolysate.

1978 • 21 citations

Formation of mutagens by heating the aqueous solution of amino acids and some nitrogenous compounds with addition of glucose.

1980 • 20 citations

Pyrolytic yields of 2-amino-9H-pyrido[2,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole as matagens from proteins.

1979 • 20 citations

Metabolic activation of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido[4,3-b]indole(Trp-P-2) by isolated rat liver nuclei

1981 • 20 citations

Some antitumor derivatives of ellipticine deprived of mutagenic properties

1978 • 20 citations

Proline enhances mutagen formation in ground beef during frying

1980 • 19 citations

Mutagenic Analysis as a Means of Detecting Carcinogens in Foods

1978 • 19 citations

Mutagen formation in a model beef boiling system III. purification and identification of three heterocyclic amine mutagens‐carcinogens

1985 • 19 citations

Mutagenicity screening of foods. II. Results with fruits and vegetables

1984 • 18 citations

Induction of carcinogen activation enzyme(s) by feeding of a carcinogenic tryptophan pyrolysate correlates to sex difference in the carcinogenesis of the mouse.

1982 • 18 citations

Metabolic activation of 1-methyl-3-amino-5H-pyrido[4,3-b]indole and several structurally related mutagens

1981 • 18 citations

Effect of methyl substitution on mutagenicity of 2-amino-dipyrido [1,2-a:3′,2′-d] imidazole, Glu-P-2

1980 • 17 citations

Induction of bladder cancer in mice by implanting pellets containing tryptophan pyrolysis products

1982 • 17 citations

DNA‐biding of IQ, Me‐IQ and Me‐IQx, strong mutagens found in broiled foods

1982 • 17 citations

A source of error in mutagen testing of foods

1981 • 16 citations

Chromosome Aberrations and Sister Chromatid Exchanges Induced by Tryptophan Pyrolysates, Trp-P-1 and Trp-P-2, in Cultured Human and Chinese Hamster Cells

1980 • 16 citations

Metabolic activation of Trp-P-2, a tryptophan-pyrolysis mutagen by isolated rat hepatocytes

1983 • 16 citations

Formation of mutagens in boiled pork extract

1982 • 16 citations

Formation of mutagenic derivatives from tryptophan pyrolysis products (Trp P1 and Trp P2) by rat intestinal S9 fraction

1983 • 15 citations

Crystal and molecular structures of 2‐amino‐3‐methylimidazo‐[4,5‐f]‐ quinoline, a novel potent mutagen found in broiled food

1980 • 15 citations

Liver cancer and precancerous changes in rats induced by the basic fraction of tryptophan pyrolysate

1981 • 14 citations

Structural elucidation of a mutagenic metabolite of 3-amino-1-methyl-5H-pyrido[4,3-b]indole.

1981 • 14 citations

Formation of mutagens by heating creatine and amino acids.

1982 • 14 citations

Mutagenicity of 1,5(or 7)-dimethyl-2,3,6,7-tetrahydro-1H,5H-biscyclopentapyrazine obtained from a cyclotene/ammonia browning model system

1980 • 14 citations

Effect of heating methods on mutagenic activity and yield of mutagenic compounds in pyrolysis products of protein.

1980 • 13 citations

Interaction of mutagens isolated from L-glutamic acid pyrolysate with DNA

1980 • 13 citations

Activation of 2-amino-3-methylimidazo[4,5-ƒ]quinoline and 2-aminofluorene for bacterial mutagenesis by primary monolayer cultures of adult rat hepatocytes

1983 • 13 citations

Reaction of DNA with a mutagenic 3-N, N-acetoxyacetylamino-4, 6-dimethyldipyrido[1, 2-a:3′, 2′-d]imidazole (N-AcO-AGlu-P-3) related to glutamic acid pyrolysates

1985 • 13 citations

Interactions between the active metabolite of tryptophan pyrolysate mutagen, N-hydroxy-Trp-P-2, and lipids: The role of lipid peroxides in the conversion of N-hydroxy-Trp-P-2 to non-reactive forms

1983 • 12 citations

Occurrence of mutagens in canned foods

1984 • 11 citations

Priorities assessment for studies of mutagen production in cooked foods1

1981 • 11 citations

Formation of mutagens by Heating creatine or amino acids with addition or fatty acids.

1980 • 10 citations

Presence of 3-amino-β-carbolines (3-amino-9H-pyrido-[3,4-b]indoles), effectors in the induction of sister-chromatid exchanges, in protein pyrolysates

1983 • 10 citations

Chromosomal aberrations and morphological transformation of hamster embryonic cells induced by L-tryptophan pyrolyzate in vitro

1978 • 8 citations

Induction of 8-azaguanine or ouabain resistant somatic mutation of Chinese hamster lung cells by treatment with tryptophan pyrolysis products

1980 • 7 citations

Detection of genotoxicity in fried bacon by the Salmonella/mammalian microsome mutagenicity assay

1983 • 7 citations

Mutagenicity of the pyrolysis products of ammonium salts.

1982 • 6 citations

Differences in observed mutagenicity associated with the extraction of mutagens from cooked fish

1983 • 6 citations

Activation of Trp‐P‐1 and Trp‐P‐2in vitroandin vivo

1981 • 5 citations

Mutagenicity of intermediates produced in the early stage of the browning reaction of triose reductone with nucleic acid related compounds on bacterial tests.

1980 • 5 citations

Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo.

1982 • 4 citations

Analysis of mutagenic amino acid pyrolyzates with a fused silica capillary column

1984 • 4 citations

Ultrastructural and biochemical alterations induced by tryptophan pyrolysis products on rat hepatocytes in primary culture. I. Action on the transcriptional process

1983 • 4 citations

The effect of pyrolysis products of d,l-tryptophan, harman and norharman on the mutagenicity of carcinogens benzo[a]pyrene and 2-aminofluorene in Salmonella/microsome test

1982 • 2 citations

Studies on mutagenicity testing for chemicals using reverse mutations in cultured human diploid cells

1978 • 1 citations