Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

1992 • 684 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive Selection of Thymocytes

1995 • 604 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase.

1995 • 256 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

A human‐human hybridoma system based on a fast‐growing mutant of the ARH‐77 plasma cell leukemia‐derived line

1982 • 214 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

1991 • 172 citations

An Altered Position of the α2 Helix of MHC Class I Is Revealed by the Crystal Structure of HLA-B*3501

1996 • 160 citations

Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity.

1993 • 149 citations

Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.

1986 • 143 citations

How αβ T-cell receptors ‘see’ peptide/MHC complexes

1993 • 124 citations

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

1995 • 121 citations

Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries.

1995 • 99 citations

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.

1993 • 97 citations

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

1995 • 89 citations

Recognition of multiple peptide cores by a single T cell receptor.

1995 • 84 citations

High-Efficiency Expression and Solubilization of Functional T Cell Antigen Receptor Heterodimers

1992 • 73 citations

Are MHC-bound peptides a nuisance for positive selection?

1994 • 61 citations

Intramolecular mimicry. Identification and analysis of two cross-reactive T cell epitopes within a single protein.

1995 • 55 citations

Measuring interactions of MHC class I molecules using surface plasmon resonance

1995 • 53 citations

Mapping T cell recognition: the identification of a T cell receptor residue critical to the specific interaction with an influenza hemagglutinin peptide

1995 • 37 citations

Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes

1989 • 37 citations

A functionally significant allelic polymorphism in a T cell receptor Vβ gene segment

1996 • 13 citations

Detergent enhances binding of a secreted HLA-A2 molecule to solid phase peptides

1991 • 4 citations