Pharmacology of Protein Kinase Inhibitors

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Modulator protein as a component of the myosin light chain kinase from chicken gizzard

1978 • 488 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

K-252a, a potent inhibitor of protein kinase C from microbial origin.

1986 • 332 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

Autophosphorylation reversibly regulates the Ca2+/calmodulin-dependence of Ca2+/calmodulin-dependent protein kinase II.

1986 • 293 citations

Reversible generation of a Ca2+-independent form of Ca2+(calmodulin)-dependent protein kinase II by an autophosphorylation mechanism.

1986 • 270 citations

Cyclic nucleotide-independent protein kinases from rabbit reticulocytes. Purification of casein kinases.

1979 • 266 citations

Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus

1989 • 249 citations

Purification and Cahracyterization of te Brain Calmodulin‐Dependent Protein Kinase (Kinase II), Which Is involved in the Activtion of Tryptophan 5‐Monooxygnase

1983 • 245 citations

Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

1984 • 152 citations

Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus

1991 • 123 citations

Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones.

1989 • 121 citations

1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion.

1986 • 117 citations

A specific inhibitor for tyrosine protein kinase from Pseudomonas.

1986 • 105 citations

Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine

1988 • 102 citations

Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols

1982 • 102 citations

The modulatory role of myosin light chain phosphorylation in human platelet activation

1986 • 101 citations

The protein kinase C inhibitors H-7 and H-9 fail to inhibit human neutrophil activation

1986 • 95 citations

Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation

1986 • 56 citations

Protein kinase C inhibitor H‐7 alters the actin cytoskeleton of cultured cells

1989 • 54 citations

Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.

1989 • 47 citations

UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium.

1989 • 43 citations

Inhibition of tyrosine protein kinase by synthetic erbstatin analogs.

1987 • 42 citations

Inhibition of human neutrophil chemotaxis by the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine.

1987 • 41 citations

A selective Ca2+calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells

1991 • 35 citations

The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: Effects of leupeptin and the protein kinase C inhibitor H-7

1987 • 34 citations

Tumor promotion and depletion of protein kinase C in epidermal JB6 cells

1989 • 28 citations

Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion.

1988 • 28 citations

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase

1986 • 22 citations

A calmodulin antagonist (W-7) and a protein kinase C inhibitor (H-7) have no effect on atrial natriuretic peptide release induced by atrial stretch

1988 • 18 citations

Concanavalin A- and calcium-dependent phosphorylation of a protein of 80 kDa in mouse lymphocytes rendered permeable to exogenously added [γ-32P]ATP

1986 • 10 citations