Update in Endocrine Autoimmunity

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

2007 • 9,332 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Epidemiology and Estimated Population Burden of Selected Autoimmune Diseases in the United States

1997 • 1,628 citations

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

2007 • 1,426 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

2007 • 1,358 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

THE NOD MOUSE: A Model of Immune Dysregulation

2004 • 1,080 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

2007 • 976 citations

Incidence of Diabetes in Youth in the United States

2007 • 971 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

A HapMap harvest of insights into the genetics of common disease

2008 • 887 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes

2004 • 741 citations

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk

2008 • 709 citations

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

2006 • 677 citations

Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study

2008 • 655 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

NALP1in Vitiligo-Associated Multiple Autoimmune Disease

2007 • 602 citations

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

2005 • 597 citations

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

2007 • 562 citations

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy

2006 • 561 citations

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

2007 • 544 citations

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

2007 • 532 citations

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

2004 • 496 citations

The Codon 620 Tryptophan Allele of the Lymphoid Tyrosine Phosphatase (LYP) Gene Is a Major Determinant of Graves’ Disease

2004 • 464 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1

2006 • 418 citations

Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

2005 • 350 citations

Heterogeneity of Type I diabetes: analysis of monozygotic twins in Great Britain and the United States

2001 • 314 citations

Genetic association studies of complex traits: design and analysis issues

2005 • 294 citations

Autoimmune Polyendocrine Syndrome Type 1 and NALP5, a Parathyroid Autoantigen

2008 • 288 citations

Foxp3 and Natural Regulatory T Cells

2003 • 278 citations

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

2006 • 271 citations

Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance

2002 • 260 citations

Treatment of Graves’ disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study

2007 • 260 citations

Extreme genetic risk for type 1A diabetes

2006 • 245 citations

High prevalence and increasing incidence of Addison's disease in western Norway

2002 • 212 citations

Autoimmune Polyendocrine Syndrome Type 1 in Norway: Phenotypic Variation, Autoantibodies, and Novel Mutations in the Autoimmune Regulator Gene

2006 • 212 citations

A Novel Mutation of the Autoimmune Regulator Gene in an Italian Kindred with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Acting in a Dominant Fashion and Strongly Cosegregating with Hypothyroid Autoimmune Thyroiditis

2001 • 199 citations

IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity

2007 • 181 citations

Association of the TSHR gene with Graves' disease: the first disease specific locus

2005 • 176 citations

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

2008 • 164 citations

Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice

1999 • 163 citations

Thyroglobulin Is a Thyroid Specific Gene for the Familial Autoimmune Thyroid Diseases

2002 • 162 citations

B Lymphocyte Depletion with the Monoclonal Antibody Rituximab in Graves’ Disease: A Controlled Pilot Study

2007 • 148 citations

Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression

2006 • 147 citations

The Genetic Basis of Thyroid Autoimmunity

2007 • 145 citations

Update in Type 1 Diabetes

2007 • 142 citations

•Australo-Anglo-American Spondylitis Consortium (TASC), et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007 Nov; 39(11):1329-37. * Member of the consortium and T2D analysis subgroup. PMID: 17952073.

2007 • 135 citations

Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicit autoimmune polyendocrinopathy syndrome type 1 (APS‐1)

2007 • 126 citations

B cell–directed therapies for autoimmune disease and correlates of disease response and relapse

2008 • 99 citations

The insulin gene in diabetes

2002 • 98 citations

Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1

2007 • 97 citations

Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves’ disease

2008 • 94 citations

A novel and major association ofHLA-Cin Graves' disease that eclipses the classicalHLA-DRB1effect

2007 • 88 citations

A Genome-Wide Screen in 1119 Relative Pairs with Autoimmune Thyroid Disease

2006 • 83 citations

Immune Regulation by Self-Reactive T Cells is Antigen Specific

2004 • 76 citations

Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice

2004 • 68 citations

Serological Evidence of Thyroid Autoimmunity among Schoolchildren in Two Different Socioeconomic Environments

2007 • 66 citations

Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs

2006 • 64 citations

A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1

2007 • 50 citations

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

2007 • 44 citations

Autoimmune endocrine disease

2002 • 37 citations