Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

Statistical methods in cancer research. Volume I - The analysis of case-control studies.

1980 • 4,991 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

2004 • 1,720 citations

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2013 • 1,393 citations

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

2004 • 1,392 citations

Haplotype tagging for the identification of common disease genes

2001 • 1,188 citations

Genome-wide association studies: theoretical and practical concerns

2005 • 1,165 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Tolerance, not immunity, crucially depends on IL-2

2004 • 826 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Genetic associations in large versus small studies: an empirical assessment

2003 • 595 citations

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

2004 • 496 citations

Statistical Models in Epidemiology

1994 • 430 citations

Detecting Disease Associations due to Linkage Disequilibrium Using Haplotype Tags: A Class of Tests and the Determinants of Statistical Power

2003 • 424 citations

Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

1997 • 402 citations

Parameters for reliable results in genetic association studies in common disease

2002 • 237 citations

Remapping the Insulin Gene/IDDM2 Locus in Type 1 Diabetes

2004 • 222 citations

Genetic Protection from the Inflammatory Disease Type 1 Diabetes in Humans and Animal Models

2001 • 205 citations

Use of unphased multilocus genotype data in indirect association studies

2004 • 186 citations

A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins

2001 • 185 citations

The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology

2004 • 164 citations

Betting Odds and Genetic Associations

2004 • 157 citations

Generalized T2 Test for Genome Association Studies

2002 • 125 citations

Genetic epidemiology of type 1 diabetes

2003 • 112 citations

Mechanisms of genetic susceptibility to type I diabetes: beyond HLA

2004 • 100 citations

Genome Association Studies of Complex Diseases by Case-Control Designs

2003 • 82 citations

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements

2002 • 72 citations

Automated detection of point mutations using fluorescent sequence trace subtraction

1998 • 69 citations

Cost-effective analysis of candidate genes using htSNPs: a staged approach

2004 • 51 citations

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.

1990 • 41 citations

Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes

2004 • 22 citations