Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1999 • 372 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells

1996 • 272 citations

Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity

1998 • 267 citations

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

1997 • 247 citations

Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics.

1992 • 246 citations

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow.

1990 • 239 citations

Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection

1998 • 234 citations

Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

1996 • 219 citations

Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter

1999 • 209 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon-α/β during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus

1997 • 173 citations

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1999 • 167 citations

Impairment of T and B Cell Development by Treatment with a Type I Interferon

1998 • 165 citations

Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2

1999 • 145 citations

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

1995 • 134 citations

The “Clonal Selection Hypothesis” and Current Concepts of B Cell Tolerance

1996 • 126 citations

Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti–Single-Stranded DNA Transgenic Mrl/lpr Mice

1999 • 122 citations

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

1996 • 115 citations

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

1998 • 114 citations

Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice.

1991 • 111 citations

Transfer of Small Resting B Cells into Immunodeficient Hosts Results in the Selection of a Self-renewing Activated B Cell Population

1999 • 108 citations

Resident bone marrow macrophages produce type 1 interferons that can selectively inhibit interleukin-7-driven growth of B lineage cells

1995 • 95 citations

Distinct Signal Thresholds for the Unique Antigen Receptor–Linked Gene Expression Programs in Mature and Immature B Cells

1999 • 89 citations

Development of antimalaria immunity in mice lacking IFN-gamma receptor.

1995 • 87 citations

Interferon‐γ arrests proliferation and causes apoptosis in stromal cell/interleukin‐7‐dependent normal murine pre‐B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin‐positive B cells

1993 • 86 citations

Independent homeostatic regulation of B cell compartments

1997 • 82 citations

HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.

1994 • 81 citations

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells

1995 • 73 citations

Secondary V(D)J recombination in B-1 cells

1999 • 68 citations

Regulation of bone marrow lymphocyte production

1983 • 44 citations

Interferons α/β inhibit IL‐7‐induced proliferation of CD4⁻ CD8⁻ CD3⁻ CD44⁺ CD25⁺ thymocytes, but do not inhibit that of CD4⁻ CD8⁻ CD3⁻ CD44⁻ CD25⁻ thymocytes

1997 • 37 citations

Proliferation of B Cell Precursors in Bone Marrow of Pristane-Conditioned and Malaria-Infected Mice: Implications for B Cell Oncogenesis

1990 • 18 citations