Caspases disrupt mitochondrial membrane barrier function

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Caspases: killer proteases

1997 • 2,440 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Mitochondria and programmed cell death: back to the future

1996 • 508 citations

Modulation of cell death by Bcl-x _L through caspase interaction

1998 • 505 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

1998 • 450 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1997 • 336 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

1997 • 245 citations

Analysis of the membrane potential of rat‐ and mouse‐liver mitochondria by flow cytometry and possible applications

1990 • 241 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II.

1990 • 181 citations

Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers

1998 • 121 citations

Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex

1998 • 116 citations

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1997 • 73 citations

Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

1998 • 72 citations

Surface potential in rat liver mitochondria: terbium ion as a phosphorescent probe for surface potential

1983 • 23 citations

Cyclosporin A‐sensitive release of Ca²⁺from mitochondria in intact thymocytes

1997 • 9 citations