Alzheimer’s disease: the lipid connection

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Global prevalence of dementia: a Delphi consensus study

2005 • 5,214 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

1998 • 1,795 citations

Statins and the risk of dementia

2000 • 1,741 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

2001 • 1,567 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

2003 • 1,129 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

2004 • 1,063 citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 • 1,058 citations

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 • 1,032 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 • 988 citations

Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

2004 • 985 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

2003 • 933 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Dietary fat intake and the risk of incident dementia in the Rotterdam study

1997 • 873 citations

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

2002 • 795 citations

Oxidative Alterations in Alzheimer's Disease

1999 • 772 citations

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study

2006 • 717 citations

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

2001 • 706 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

2006 • 675 citations

A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model

2005 • 659 citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

2002 • 657 citations

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

1991 • 645 citations

N<scp>OTCH AND</scp>P<scp>RESENILIN</scp>: Regulated Intramembrane Proteolysis Links Development and Degeneration

2003 • 640 citations

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

2002 • 576 citations

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

2001 • 528 citations

Use of Lipid-Lowering Agents, Indication Bias, and the Risk of Dementia in Community-Dwelling Elderly People

2002 • 519 citations

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

2001 • 516 citations

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

2002 • 505 citations

Fish, meat, and risk of dementia: cohort study

2002 • 482 citations

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

2001 • 462 citations

ADAMs family members as amyloid precursor protein α‐secretases

2003 • 430 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

2002 • 419 citations

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial

2002 • 417 citations

Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

2005 • 416 citations

Cholesterol homeostasis and function in neurons of the central nervous system

2003 • 415 citations

Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism

2002 • 410 citations

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

2002 • 406 citations

Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme

2000 • 404 citations

Atorvastatin for the Treatment of Mild to Moderate Alzheimer Disease

2005 • 392 citations

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

2000 • 389 citations

Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain

1996 • 387 citations

Protein Topology of Presenilin 1

1996 • 374 citations

Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

2002 • 358 citations

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

1998 • 350 citations

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1993 • 334 citations

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.

2004 • 333 citations

Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid

2003 • 322 citations

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study

2003 • 311 citations

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

2000 • 300 citations

Chemistry and functional distribution of sulfoglycolipids

1997 • 284 citations

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

2006 • 281 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin

2002 • 276 citations

Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years

1994 • 267 citations

Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein

1999 • 260 citations

The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1

2003 • 259 citations

Protein Sorting upon Exit from the Endoplasmic Reticulum

2001 • 249 citations

Aging and the Occurrence of Dementia

1999 • 248 citations

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

2006 • 236 citations

Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain

1995 • 230 citations

Metabolic and functional aspects of sulfogalactolipids

1994 • 225 citations

Regulation of Amyloid Precursor Protein Cleavage

1999 • 224 citations

Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease

1999 • 220 citations

Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia

2001 • 220 citations

Purification and Characterization of the Human γ-Secretase Complex

2004 • 219 citations

Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice

2002 • 218 citations

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

1996 • 213 citations

Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch

2002 • 212 citations

Mice Lacking the Metalloprotease-Disintegrin MDC9 (ADAM9) Have No Evident Major Abnormalities during Development or Adult Life

2002 • 209 citations

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1997 • 205 citations

Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part V: The discovery of the statins and the end of the controversy

2006 • 200 citations

A Nine-transmembrane Domain Topology for Presenilin 1

2005 • 194 citations

The β-Secretase, BACE: A Prime Drug Target for Alzheimer's Disease

2001 • 181 citations

Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids

1997 • 178 citations

Lipid Alterations in the Earliest Clinically Recognizable Stage of Alzheimers Disease: Implication of the Role of Lipids in the Pathogenesis of Alzheimers Disease

2005 • 174 citations

The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease

2002 • 168 citations

Neural membrane phospholipids in alzheimer disease

1995 • 156 citations

Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer?s disease

2003 • 156 citations

Assembly, Trafficking and Function of γ-Secretase

2006 • 147 citations

Ceramide as a second messenger: sticky solutions to sticky problems

2000 • 147 citations

Brain membrane cholesterol domains, aging and amyloid beta-peptides

2002 • 147 citations

Plasma 24S-hydroxycholesterol

2000 • 140 citations

Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]

2005 • 123 citations

Fatty Acid Oxidation in the Pathogenesis of Alzheimer's Disease

2005 • 108 citations

Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions

1995 • 103 citations

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42

2004 • 101 citations

Plasma Levels of β-Amyloid(1-40), β-Amyloid(1-42), and Total β-Amyloid Remain Unaffected in Adult Patients With Hypercholesterolemia After Treatment With Statins

2004 • 99 citations

GM1 ganglioside regulates the proteolysis of amyloid precursor protein

2004 • 97 citations

Plasmalogens, phospholipases A and signal transduction

1995 • 94 citations

Secreted Form of Amyloid Precursor Protein Enhances Basal Glucose and Glutamate Transport and Protects Against Oxidative Impairment of Glucose and Glutamate Transport in Synaptosomes by a Cyclic GMP‐Mediated Mechanism

1999 • 94 citations

Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study.

2003 • 86 citations

Membrane Instability, Plasmalogen Content, and Alzheimer's Disease

1998 • 80 citations

Neuronal localization of the TNF? converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

2001 • 80 citations

Gangliosides in Cerebrospinal Fluid in 'Probable Alzheimer's Disease'

1991 • 79 citations

Furin is an endogenous regulator of α-secretase associated APP processing

2006 • 74 citations

Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

1998 • 73 citations

Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation

2003 • 72 citations

Lipoproteins and lipid peroxidation in Alzheimer's disease.

2003 • 68 citations

Effects of Sphingosine and Other Sphingolipids on Protein Kinase C

2000 • 67 citations

Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia

1995 • 67 citations

Ceramide Involvement in Apoptosis and Apoptotic Diseases

2006 • 59 citations

Plasmalogens, Docosahexaenoic Acid and Neurological Disorders

2003 • 57 citations

Topology of the C-Terminal Fragment of Human Presenilin 1

2005 • 50 citations

Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on Protein Kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts

2001 • 48 citations

Dramatic increase of α-hydroxyaldehydes derived from plasmalogens in the aged human brain

1997 • 47 citations

Oxidative Mechanisms in β-Amyloid Cytotoxicity

1996 • 47 citations

The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted

2003 • 46 citations

Altered membrane fluidity and lipid raft composition in presenilin-deficient cells

2006 • 46 citations

Effect of tumor necrosis factor‐α converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons

2002 • 40 citations

Processing of the Alzheimer's Disease ΒZA4 Amyloid Protein Precursor (APP)

1991 • 36 citations

Brain gangliosides in Alzheimer's disease.

1990 • 35 citations

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

2005 • 19 citations

Screening a series of sialyltransferases for possible BACE1 substrates

2006 • 16 citations

Alzheimer's β-secretase cleaves a glycosyltransferase as a physiological substrate

2003 • 15 citations

The Pathology of the Amyloid A4 Precursor of Alzheimer's Disease

1989 • 9 citations