BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Purification and cloning of amyloid precursor protein β-secretase from human brain

1999 • 1,589 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

1999 • 1,440 citations

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

2000 • 1,259 citations

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 • 1,072 citations

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 • 1,032 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 • 988 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

1997 • 783 citations

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

2000 • 777 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

2000 • 300 citations

Construction of Gene Targeting Vectors from λKOS Genomic Libraries

1999 • 101 citations

A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein

2001 • 78 citations

Use of BRL-conditioned medium in combination with feeder layers to isolate a diploid embryonal stem cell line

1989 • 71 citations

Normal and Abnormal Biology of the Beta-Amyloid Precursor Protein

1994 • 25 citations

Two automated locomotor activity tests for dopamine autoreceptor agonists

1986 • 5 citations