Downregulation of Wnt4 and upregulation of Wnt5a expression by epithelialmesenchymal transition in human squamous carcinoma cells

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

1998 • 2,028 citations

Molecular classification of cutaneous malignant melanoma by gene expression profiling

2000 • 2,011 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

2000 • 992 citations

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

2002 • 945 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

1999 • 699 citations

Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

2000 • 677 citations

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

2002 • 577 citations

Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer

2002 • 573 citations

Snail Induction of Epithelial to Mesenchymal Transition in Tumor Cells Is Accompanied by MUC1 Repression andZEB1 Expression

2002 • 467 citations

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

2001 • 465 citations

DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT

2002 • 417 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

1996 • 405 citations

Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity

1983 • 388 citations

Identification of Distinct Classes and Functional Domains of Wnts through Expression of Wild-Type and Chimeric Proteins in Xenopus Embryos

1995 • 314 citations

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

2002 • 308 citations

Differential Transformation of Mammary Epithelial Cells by Wnt Genes

1994 • 305 citations

Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity

1984 • 281 citations

Loss of E-cadherin Expression in Melanoma Cells Involves Up-regulation of the Transcriptional Repressor Snail

2001 • 281 citations

New mode of DNA binding of multi-zinc finger transcription factors: delta EF1 family members bind with two hands to two target sites

1999 • 262 citations

Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture.

1986 • 252 citations

Expression of Wnt signalling pathway genes during tooth development

1999 • 242 citations

Differential transformation of mammary epithelial cells by Wnt genes.

1994 • 237 citations

Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro

2001 • 212 citations

Mutated APC and Asef are involved in the migration of colorectal tumour cells

2003 • 212 citations

Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.

2002 • 209 citations

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

1994 • 197 citations

Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas

2003 • 195 citations

Aberrant expression of the growth factor Wnt-5A in human malignancy.

1995 • 191 citations

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

1990 • 188 citations

Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene

1992 • 178 citations

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas

2002 • 173 citations

Regulation of Epithelial Cell Migration and Tumor Formation by β-Catenin Signaling

2002 • 162 citations

Wnt5a cloning, expression, and up-regulation in human primary breast cancers.

1995 • 154 citations

Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo

2002 • 154 citations

Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development

1992 • 144 citations

DWnt4 Regulates Cell Movement and Focal Adhesion Kinase during Drosophila Ovarian Morphogenesis

2002 • 138 citations

The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

1992 • 138 citations

Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma

1997 • 134 citations

Evidence for the involvement of the Wnt 2 gene in human colorectal cancer.

1996 • 115 citations

The development of eyespot patterns on butterfly wings: morphogen sources or sinks?

1992 • 111 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

The Wnt-1 (int-1) Oncogene Promoter and Its Mechanism of Activation by Insertion of Proviral DNA of the Mouse Mammary Tumor Virus

1990 • 59 citations

Characterization ofWntGene Expression in Murine Skin: Possible Involvement of Epidermis-Derived Wnt-4 in Cutaneous Epithelial–Mesenchymal Interactions

1998 • 49 citations

Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a.

1997 • 42 citations

The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.

1990 • 38 citations

Inactivation patterns of the p16 (INK4a) gene in oral squamous cell carcinoma cell lines

1999 • 35 citations

Expression of E‐cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo

1999 • 33 citations

Expression of telomerase components in oral keratinocytes and squamous cell carcinomas

2001 • 31 citations

Expression of Wnt5a Is Downregulated by Extracellular Matrix and Mutated c-Ha-ras in the Human Mammary Epithelial Cell Line MCF-10A

1997 • 29 citations

High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer

1998 • 28 citations

Growth of normal oral keratinocytes and squamous cell carcinoma cells in a novel protein-free defined medium

1999 • 7 citations