Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O ⁶ -benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Comparison of O⁶-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1986 • 277 citations

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer

1996 • 253 citations

The Prevention of Thymic Lymphomas in Transgenic Mice by Human O ⁶ -Alkylguanine-DNA Alkyltransferase

1993 • 238 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.

1994 • 198 citations

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.

1990 • 186 citations

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

1992 • 183 citations

Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients

1984 • 171 citations

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

1993 • 152 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

1995 • 123 citations

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells

1995 • 122 citations

ACCELERATED PAPER: Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1996 • 116 citations

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

1996 • 113 citations

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells.

1985 • 113 citations

Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer

1995 • 103 citations

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

1994 • 91 citations

Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6- benzylguanine plus BCNU

1996 • 85 citations

Leukaemia complicating treatment for Hodgkin's disease: the experience of the British National Lymphoma Investigation.

1990 • 76 citations

Synergistic efficacy of O6benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

1993 • 72 citations

O6-methylguanine residues elicit DNA repair synthesis by human cell extracts

1993 • 68 citations

Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.

1994 • 66 citations

O 6 -Alkylguanine-DNA Alkyltransferase: A Target for the Modulation of Drug Resistance

1995 • 66 citations

Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase.

1988 • 63 citations

Comparison of the inactivation of mammalian and bacterial O⁶-alkylguanine-DNA alkyltransferases by O⁶-benzylguanine and O⁶-methylguanine

1991 • 55 citations

Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase.

1989 • 47 citations

Retrovirus‐mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells

1994 • 46 citations

Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine

1992 • 45 citations

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.

1990 • 42 citations

Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.

1996 • 37 citations

Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors.

1987 • 32 citations

Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.

1995 • 32 citations

Formation of DNA interstrand cross-links by the novel chloroethylating agent 2-chloroethyl(methylsulfonyl)methanesulfonate: suppression by O6-alkylguanine-DNA alkyltransferase purified from human leukemic lymphoblasts.

1987 • 30 citations

Effect ofO 6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer

1993 • 28 citations

Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors.

1996 • 27 citations

Retroviral transfer and expression of the human multiple drug resistance (MDR) gene in peripheral blood progenitor cells.

1996 • 25 citations

Cytokinetic evaluation in human head and neck cancer by autoradiography and DNA cytofluorometry

1980 • 21 citations

The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene

1995 • 20 citations

Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.

1996 • 18 citations