Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR TO HARVEST CIRCULATING HAEMOPOIETIC STEM CELLS FOR AUTOTRANSPLANTATION

1989 • 776 citations

Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients

1991 • 519 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells

1990 • 300 citations

Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia.

1984 • 236 citations

Autologous bone marrow transplantation in acute leukemia: a phase I study of in vitro treatment of marrow with 4- hydroperoxycyclophosphamide to purge tumor cells

1985 • 211 citations

Recombinant human granulocyte-macrophage colony-stimulating factor reduces hematologic toxicity and widens clinical applicability of high-dose cyclophosphamide treatment in breast cancer and non-Hodgkin's lymphoma.

1990 • 203 citations

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

1985 • 194 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.

1994 • 161 citations

Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer

1992 • 144 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Transfer and expression of the human multiple drug resistance gene in human CD34+ cells

1994 • 137 citations

Stimulation of hematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte-macrophage colony-stimulating factor

1988 • 132 citations

Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells.

1988 • 118 citations

Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines.

1985 • 84 citations

High-dose sequential chemo-radiotherapy with peripheral blood progenitor cell support for relapsed or refractory Hodgkin's disease — A 6-year update

1993 • 67 citations

Genomic structure of the human cytosolic aldehyde dehydrogenase gene

1989 • 65 citations

Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines

1985 • 63 citations

Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.

1987 • 54 citations

Clinical pharmacokinetics of cyclophosphamide and metabolites with and without SR-2508.

1994 • 43 citations

Transplantation of stem cells enriched by immunoadsorption.

1992 • 20 citations

Hematopoiesis in limiting dilution cultures: influence of cytokines on human hematopoietic progenitor cells.

1990 • 13 citations

Cellular glutathione as a protective agent against 4-hydroperoxycyclophosphamide cytotoxicity in K-562 cells

1990 • 7 citations