Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Genetic studies of the lac repressor

1977 • 610 citations

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

1990 • 475 citations

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Three-dimensional structure of ribonuclease H from E. coli

1990 • 348 citations

Atomic Structure of the DNA Repair [4Fe-4S] Enzyme Endonuclease III

1992 • 289 citations

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.

1985 • 221 citations

Improvement of macromolecular electron-density maps by the simultaneous application of real and reciprocal space constraints

1993 • 194 citations

Repair of O6-methylguanine in adapted Escherichia coli.

1978 • 180 citations

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

1982 • 178 citations

Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis.

1977 • 178 citations

Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.

1982 • 172 citations

Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.

1984 • 162 citations

X-Ray Structure of T4 Endonuclease V: an Excision Repair Enzyme Specific for a Pyrimidine Dimer

1992 • 143 citations

Biomolecular Structure, Conformation, Function, and Evolution

1981 • 132 citations

Functional domains and methyl acceptor sites of the Escherichia coli ada protein.

1988 • 107 citations

Repair of O-alkylpyrimidines in mammalian cells: a present consensus.

1988 • 104 citations

Structural studies of the O6meG.cntdot.C interaction in the d(C-G-C-G-A-A-T-T-C-O6meG-C-G) duplex

1986 • 104 citations

High-resolution structure of a mutagenic lesion in DNA.

1990 • 93 citations

Base pair mismatches and carcinogen-modified bases in DNA: an NMR study of G.cntdot.T and G.cntdot.O4meT pairing in dodecanucleotide duplexes

1988 • 78 citations

Kinetic and DNA-Binding Properties of Recombinant Human O6-Methylguanine-DNA Methyltransferase

1993 • 53 citations

The Escherichia coli O6-methylguanine-DNA methyltransferase does not repair promutagenic O6-methylguanine residues when present in Z-DNA.

1985 • 46 citations

In vitro proteolytic cleavage of the Escherichia coli Ada protein by the ompT gene product

1989 • 44 citations

Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogs: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer

1992 • 37 citations

Interaction of Ada protein with DNA examined by fluorescence anisotropy of the protein

1990 • 28 citations

MutantEscherichia coliAda proteins simultaneously defective in the repair of O⁶-metbylguanine and in gene activation

1986 • 28 citations

N-Methyl-N′-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis

1990 • 25 citations

What is evolution playing at?

1993 • 11 citations

Crystallization of O6-methylguanine-DNA methyltransferase from Escherichia coli

1988 • 11 citations