The c-Myc target gene network

Emergence of Scaling in Random Networks

1999 • 34,466 citations

Error and attack tolerance of complex networks

2000 • 6,651 citations

Network motifs in the transcriptional regulation network of Escherichia coli

2002 • 3,012 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules

2003 • 2,220 citations

Structure and function of the feed-forward loop network motif

2003 • 1,817 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

A Genomic Regulatory Network for Development

2002 • 1,538 citations

Reverse engineering of regulatory networks in human B cells

2005 • 1,408 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

c-MYC: more than just a matter of life and death

2002 • 1,147 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs

2004 • 1,079 citations

Genomic targets of the human c-Myc protein

2003 • 956 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

2000 • 816 citations

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

2004 • 784 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Structure and evolution of transcriptional regulatory networks

2004 • 751 citations

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

2004 • 750 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

2005 • 647 citations

Mouse Development and Cell Proliferation in the Absence of D-Cyclins

2004 • 630 citations

Drosophila Myc Regulates Organ Size by Inducing Cell Competition

2004 • 591 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

dMyc Transforms Cells into Super-Competitors

2004 • 570 citations

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

2003 • 524 citations

Skp2 Regulates Myc Protein Stability and Activity

2003 • 492 citations

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

2003 • 481 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

2002 • 478 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Osprey: a network visualization system

2003 • 475 citations

Translocations involving c-myc and c-myc function

2001 • 465 citations

Myc pathways provoking cell suicide and cancer

2003 • 461 citations

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

2005 • 459 citations

The myc Oncogene: omplex

2002 • 458 citations

Identification of CDK4 as a target of c-MYC

2000 • 457 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

1997 • 447 citations

c-Myc regulates mammalian body size by controlling cell number but not cell size

2001 • 444 citations

An initial blueprint for myogenic differentiation

2005 • 436 citations

Mechanisms of apoptosis by c-Myc

1999 • 430 citations

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

2001 • 428 citations

Direct activation of RNA polymerase III transcription by c-Myc

2003 • 427 citations

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc

1999 • 427 citations

Myc represses transcription through recruitment of DNA methyltransferase corepressor

2004 • 425 citations

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

2001 • 408 citations

Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes

2002 • 399 citations

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

1999 • 394 citations

Genomic binding by theDrosophilaMyc, Max, Mad/Mnt transcription factor network

2003 • 392 citations

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

2005 • 385 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

1996 • 358 citations

Evolution of transcription factors and the gene regulatory network in Escherichia coli

2003 • 349 citations

Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays

2004 • 343 citations

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

2001 • 334 citations

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

2001 • 319 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

1999 • 316 citations

The transcriptional program of a human B cell line in response to Myc

2001 • 312 citations

Functional Network Analysis Reveals Extended Gliomagenesis Pathway Maps and Three Novel MYC-Interacting Genes in Human Gliomas

2005 • 312 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

THE MANY ROLES OF c-Myc IN APOPTOSIS

1998 • 310 citations

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

2003 • 303 citations

Analysis of genomic targets reveals complex functions of MYC

2004 • 296 citations

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

1993 • 294 citations

Growth Factor-Induced Delayed Early Response Genes

1992 • 287 citations

Gene expression phenotypic models that predict the activity of oncogenic pathways

2003 • 264 citations

Identification of c-myc responsive genes using rat cDNA microarray.

2000 • 261 citations

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

2002 • 256 citations

The yeast coexpression network has a small‐world, scale‐free architecture and can be explained by a simple model

2004 • 252 citations

A role for transcriptional repression of p21 ^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

2000 • 249 citations

Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c - myc and its regulated genes

2002 • 225 citations

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

2003 • 224 citations

Genetic regulators of large-scale transcriptional signatures in cancer

2006 • 222 citations

An extended transcriptional regulatory network of Escherichia coli and analysis of its hierarchical structure and network motifs

2004 • 218 citations

A library of gene expression signatures to illuminate normal and pathological lymphoid biology

2006 • 217 citations

Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis.

1994 • 214 citations

Transcriptional repression by Myc

2003 • 211 citations

c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism

2001 • 199 citations

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

2002 • 194 citations

The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

2002 • 193 citations

Growth factor-induced delayed early response genes.

1992 • 192 citations

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

2000 • 188 citations

Quantitative proteomic analysis of Myc oncoprotein function

2002 • 186 citations

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

2003 • 185 citations

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

2003 • 182 citations

The Max Network Gone Mad

2001 • 181 citations

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

2003 • 179 citations

A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation

2004 • 178 citations

New Myc-interacting proteins: a second Myc network emerges

1999 • 178 citations

A role for c-Myc in the regulation of ribosomal RNA processing

2003 • 178 citations

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

2004 • 176 citations

An E-Box-Mediated Increase in cad Transcription at the G₁/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

1995 • 169 citations

dMyc is required for larval growth and endoreplication in Drosophila

2004 • 161 citations

Myc represses the growth arrest gene gadd45

1997 • 149 citations

Identifying Genes Regulated in a Myc-dependent Manner

2002 • 128 citations

c-Myc Overexpression Uncouples DNA Replication from Mitosis

1999 • 128 citations

Myc-mediated transformation: the repression connection

1999 • 126 citations

Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation

2001 • 124 citations

Reconstructing MYC: Figure 1.

2003 • 123 citations

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

2000 • 123 citations

c-MYC apoptotic function is mediated by NRF-1 target genes

2003 • 123 citations

Disentangling the MYC web

2002 • 120 citations

Myc

2004 • 109 citations

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites

2003 • 105 citations

DrosophiladMyc is required for ovary cell growth and endoreplication

2004 • 103 citations

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

2001 • 101 citations

Lack of Cyclin-Dependent Kinase 4 Inhibits c-myc Tumorigenic Activities in Epithelial Tissues

2004 • 99 citations

Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

2002 • 93 citations

Myc represses transcription of the growth arrest gene gas1

1997 • 88 citations

Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication

2000 • 78 citations

Overexpression of Myc suppresses CCAAT transcription factor/nuclear factor 1-dependent promoters in vivo.

1993 • 64 citations

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

2000 • 63 citations

Transcriptional suppression of cellular gene expression by c-Myc.

1991 • 62 citations

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

2004 • 54 citations

Targeting c-Myc-activated genes with a correlation method: Detection of global changes in large gene expression network dynamics

2005 • 54 citations

Identification of novel Myc target genes with a potential role in lymphomagenesis

2004 • 52 citations

Association of the decreased expression of alpha3beta1 integrin with the altered cell: environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells.

1998 • 48 citations

Transcriptional Regulation of Myelopoiesis

2002 • 45 citations

DNA-binding domain of human c-Myc produced in Escherichia coli.

1989 • 40 citations

Complementation of Myc-dependent cell proliferation by cDNA expression library screening

2000 • 34 citations

In silico identification of transcriptional regulators associated with c-Myc

2004 • 28 citations

Promoter-binding and repression of PDGFRB by c-Myc are separable activities

2004 • 28 citations

c-Myc transactivation domain-associated kinases: Questionable role for map kinases in c-Myc phosphorylation

1999 • 26 citations

Characterization of the Murine Nramp1 Promoter

2003 • 12 citations

c-Myc represses the murine Nrampl promoter

2002 • 12 citations