The Max Network Gone Mad

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Cancer Cell Cycles

1996 • 5,379 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

Targeted expression of MYCN causes neuroblastoma in transgenic mice

1997 • 830 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

1997 • 565 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

Differential expression of myc family genes during murine development

1986 • 542 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment

1986 • 536 citations

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

2000 • 502 citations

Genetics of programmed cell death in C. elegans: past, present and future

1998 • 486 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

2000 • 447 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Myc and Max associate in vivo.

1992 • 428 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

1999 • 394 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

1995 • 372 citations

The role of c-myc in cell growth

1993 • 365 citations

An alternative pathway for gene regulation by Myc

1997 • 365 citations

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

1992 • 365 citations

Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death

1994 • 365 citations

The Tumor Suppressor Protein p16INK4a

1997 • 332 citations

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation

2000 • 322 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

1992 • 314 citations

The T-box gene family

1998 • 307 citations

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

1993 • 294 citations

SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex

1998 • 288 citations

The INK4a/ARF tumor suppressor: one gene—two products—two pathways

1998 • 286 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

1999 • 277 citations

Control of cell proliferation by Myc

1998 • 251 citations

c-Myc and apoptosis

1995 • 251 citations

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.

1997 • 248 citations

T-box genes: what they do and how they do it

1999 • 241 citations

Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers.

1992 • 230 citations

Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

1994 • 227 citations

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

1994 • 224 citations

The T genes in embryogenesis

1994 • 215 citations

SAP30, a Component of the mSin3 Corepressor Complex Involved in N-CoR-Mediated Repression by Specific Transcription Factors

1998 • 212 citations

Mutation of the MXI1 gene in prostate cancer

1995 • 207 citations

Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse

1993 • 206 citations

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth

1998 • 197 citations

c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.

1988 • 195 citations

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

2000 • 194 citations

Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus

1993 • 193 citations

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

1997 • 190 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

New Myc-interacting proteins: a second Myc network emerges

1999 • 178 citations

Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif

1999 • 174 citations

Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene

1986 • 173 citations

Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.

1989 • 172 citations

Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

1997 • 171 citations

An E-Box-Mediated Increase in cad Transcription at the G₁/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

1995 • 169 citations

Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells

1999 • 167 citations

Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

1993 • 164 citations

myc oncogenes: activation and amplification

1987 • 147 citations

Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis.

1995 • 146 citations

Effects of c-myc Expression on Cell Cycle Progression

1994 • 141 citations

Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

2000 • 138 citations

Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation

1992 • 130 citations

myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome

1998 • 130 citations

Sequence-specific DNA binding by Myc proteins.

1991 • 130 citations

Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor

1997 • 129 citations

Sequential expression of the MAD family of transcriptional repressors during differentiation and development

1998 • 129 citations

Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences

1993 • 123 citations

Expression and Activity of L-Myc in Normal Mouse Development

1996 • 119 citations

Identification and Characterization of Specific DNA-binding Complexes Containing Members of the Myc/Max/Mad Network of Transcriptional Regulators

1998 • 116 citations

Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers

1993 • 112 citations

N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc.

1989 • 112 citations

A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis

1991 • 107 citations

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

1997 • 103 citations

Mlx, a Novel Max-like BHLHZip Protein That Interacts with the Max Network of Transcription Factors

1999 • 102 citations

c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways.

1996 • 101 citations

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice

2000 • 97 citations

Essential role for Max in early embryonic growth and development

2000 • 95 citations

Max and c-Myc/Max DNA-binding activities in cell extracts.

1992 • 94 citations

max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors.

1992 • 92 citations

Angiogenesis is an early event in the generation of myc-induced lymphomas

2000 • 90 citations

Direct Examination of Histone Acetylation on Myc Target Genes Using Chromatin Immunoprecipitation

2000 • 90 citations

Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?

2000 • 84 citations

Commonly occurring loss and mutation of theMXI1 gene in prostate cancer

1998 • 82 citations

Proto-oncogene Sno expression, alternative isoforms and immediate early serum response

1997 • 62 citations

A 13-Amino Acid Amphipathic α-Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A

1999 • 62 citations

Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions.

1995 • 61 citations

Snol, a novel alternatively spliced isoform of the ski protooncogene homolog, sno

1993 • 60 citations

Targeted Deletion of the S-Phase-Specific Myc Antagonist Mad3 Sensitizes Neuronal and Lymphoid Cells to Radiation-Induced Apoptosis

2001 • 57 citations

The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability

1998 • 52 citations

Identification of two distinct tumor-suppressor loci on the long arm of chromosome 10 in small cell lung cancer

1998 • 49 citations

Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma

2000 • 48 citations

Sin3 corepressor function in Myc-induced transcription and transformation.

1996 • 47 citations

Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents

1999 • 44 citations

Point Mutations of the Mxil Gene are Rare in Prostate Cancers

1996 • 40 citations

c-myc Antisense Transcripts Accelerate Differentiation and Inhibit G₁ Progression in Murine Erythroleukemia Cells

1988 • 38 citations

Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways

1997 • 37 citations

Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice.

1995 • 36 citations

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

1998 • 34 citations

Analysis of the max-binding protein MNT in human medulloblastomas

1999 • 32 citations

Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1.

1999 • 32 citations

Cloning and characterization of the murine homolog of thesno proto-oncogene reveals a novel splice variant

1996 • 28 citations

Max interacting protein 1: loss of heterozygosity is frequent in desmoplastic melanoma.

1999 • 28 citations

Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc

1998 • 27 citations

Deletions in the Long Arm of Chromosome 10 in Lymphomas With t(14;18): A Pathogenetic Role of the Tumor Suppressor Genes PTEN/MMAC1 and MXI1?

1998 • 27 citations

No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters

1997 • 27 citations

Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network

1999 • 26 citations

Deletions in the Long Arm of Chromosome 10 in Lymphomas With t(14;18): A Pathogenetic Role of the Tumor Suppressor Genes PTEN/MMAC1 and MXI1?

1998 • 21 citations

Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski.

1999 • 21 citations

Lack of transcriptional repression by max homodimers

1998 • 20 citations

Mxi1 Mutations in Human Neurofibrosarcomas

1999 • 16 citations

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo

1999 • 15 citations

Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma

1996 • 13 citations

Myc Structure and Function

1997 • 10 citations