Analysis of genomic targets reveals complex functions of MYC

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

Genomic targets of the human c-Myc protein

2003 • 956 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Size Control in Animal Development

1999 • 742 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

1995 • 587 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

2003 • 524 citations

Skp2 Regulates Myc Protein Stability and Activity

2003 • 492 citations

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

2003 • 481 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

2003 • 466 citations

The myc Oncogene: omplex

2002 • 458 citations

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

2001 • 428 citations

Myc and Max associate in vivo.

1992 • 428 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1999 • 409 citations

Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes

2002 • 399 citations

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

1999 • 394 citations

Genomic binding by theDrosophilaMyc, Max, Mad/Mnt transcription factor network

2003 • 392 citations

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

2003 • 379 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1999 • 357 citations

The transcriptional program of a human B cell line in response to Myc

2001 • 312 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

2002 • 306 citations

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

2003 • 303 citations

Control of cell growth by c-Myc in the absence of cell division

1999 • 290 citations

DNA and RNA from Uninfected Vertebrate Cells Contain Nucleotide Sequences Related to the Putative Transforming Gene of Avian Myelocytomatosis Virus

1979 • 273 citations

Identification of c-myc responsive genes using rat cDNA microarray.

2000 • 261 citations

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

2002 • 256 citations

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.

1997 • 248 citations

Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes

2003 • 236 citations

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

2003 • 224 citations

Transcriptional repression by Myc

2003 • 211 citations

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

2002 • 194 citations

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

2003 • 185 citations

The role of p53-target genes in human cancer

2000 • 176 citations

No PUMA, no death

2003 • 174 citations

Isolation of p53‐target genes and their functional analysis

2004 • 167 citations

Life and death decisions by E2F-1

2003 • 162 citations

TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein.

1993 • 146 citations

Myc and Max function as a nucleoprotein complex

1992 • 143 citations

Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius

2001 • 131 citations

Identifying Genes Regulated in a Myc-dependent Manner

2002 • 128 citations

Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation.

2002 • 120 citations

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

2001 • 101 citations

Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A.

2000 • 100 citations

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

2000 • 63 citations

Genetic dissection of c-myc apoptotic pathways

2000 • 59 citations

c-Myc-Induced Genomic Instability

2003 • 56 citations

Implication of transcription factor E2F in regulation of DNA replication

1999 • 55 citations

Identification of Myc-mediated Death Response Pathways by Microarray Analysis

2002 • 27 citations

A Strategy to Identify Differentially Expressed Genes Using Representational Difference Analysis and cDNA Arrays

2001 • 18 citations

The Max network: coordinated transcriptional regulation of cell growth and proliferation.

2002 • 18 citations

Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product

2004 • 17 citations

A computerized database-scan to identify c-MYC targets

2002 • 16 citations

Implication of transcription factor E2F in regulation of DNA replication

1999 • 15 citations