Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

The spindle-assembly checkpoint in space and time

2007 • 2,120 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

A mechanism linking extra centrosomes to chromosomal instability

2009 • 1,368 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

2005 • 1,026 citations

Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

2007 • 922 citations

Risks of leukaemia and solid tumours in individuals with Down's syndrome

2000 • 847 citations

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

2002 • 814 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

2008 • 795 citations

The Polo kinase Plk4 functions in centriole duplication

2005 • 772 citations

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

2001 • 727 citations

Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

2006 • 709 citations

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

2004 • 702 citations

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.

1995 • 701 citations

Flies without Centrioles

2006 • 666 citations

Tetraploidy, aneuploidy and cancer

2007 • 651 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

2008 • 614 citations

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

2008 • 613 citations

Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice

2006 • 608 citations

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

2004 • 588 citations

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

2009 • 577 citations

Centrosome amplification drives chromosomal instability in breast tumor development

2002 • 564 citations

Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells

2001 • 556 citations

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

2004 • 552 citations

Isolation and Characterization of a Pituitary Tumor-Transforming Gene (PTTG)

1997 • 541 citations

Centrosome Amplification Can Initiate Tumorigenesis in Flies

2008 • 541 citations

Does aneuploidy cause cancer?

2006 • 528 citations

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

2000 • 523 citations

Examining the link between chromosomal instability and aneuploidy in human cells

2008 • 498 citations

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

2008 • 441 citations

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

2004 • 434 citations

Spindle Multipolarity Is Prevented by Centrosomal Clustering

2005 • 425 citations

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

2008 • 408 citations

Managing the centrosome numbers game: from chaos to stability in cancer cell division

2001 • 402 citations

Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung

1890 • 398 citations

Aneuploidy: Cells Losing Their Balance

2008 • 390 citations

Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines

2005 • 382 citations

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

2008 • 371 citations

17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

1996 • 358 citations

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

2003 • 336 citations

Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2

2004 • 314 citations

Unstable Kinetochore-Microtubule Capture and Chromosomal Instability Following Deletion of CENP-E

2002 • 312 citations

Structure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG)

1999 • 300 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 294 citations

Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency

2004 • 290 citations

The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage

2006 • 287 citations

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms

2003 • 266 citations

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

2003 • 265 citations

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

2000 • 249 citations

Tetraploidy and chromosomal instability are early events during cervical carcinogenesis

2005 • 248 citations

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

2009 • 244 citations

Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice

1987 • 243 citations

Terminal phase of cytokinesis in D-98S cells

1977 • 242 citations

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation

2006 • 241 citations

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

2007 • 218 citations

Merotelic kinetochore orientation, aneuploidy, and cancer

2008 • 212 citations

Origins and consequences of centrosome aberrations in human cancers

2006 • 210 citations

Aneuploidy: Instigator and Inhibitor of Tumorigenesis

2007 • 185 citations

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

2004 • 184 citations

Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

2004 • 183 citations

BUBR1 deficiency results in abnormal megakaryopoiesis

2003 • 182 citations

Heterozygous Deletion of Mitotic Arrest–Deficient Protein 1 (MAD1) Increases the Incidence of Tumors in Mice

2007 • 182 citations

The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation

2005 • 181 citations

A tumor profile in Down syndrome

1998 • 178 citations

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

2006 • 173 citations

Centrosome Dysfunction in Drosophila Neural Stem Cells Causes Tumors that Are Not Due to Genome Instability

2008 • 164 citations

Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells

2002 • 160 citations

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice

2007 • 159 citations

Colonic tumorigenesis in BubR1 ^+/– Apc ^{Min /+} compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

2005 • 159 citations

Monoallelic BUB1B mutations and defective mitotic‐spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome

2006 • 158 citations

Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome

2008 • 156 citations

Overexpression of Separase induces aneuploidy and mammary tumorigenesis

2008 • 155 citations

A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion

2007 • 148 citations

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

2008 • 146 citations

Extra centrosomes and/or chromosomes prolong mitosis in human cells

2008 • 145 citations

Activation of CDCA1-KNTC2, Members of Centromere Protein Complex, Involved in Pulmonary Carcinogenesis

2006 • 144 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2004 • 144 citations

Flies without a spindle checkpoint

2007 • 143 citations

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans

1999 • 139 citations

Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint

2007 • 137 citations

Overexpressed Pituitary Tumor-Transforming Gene Causes Aneuploidy in Live Human Cells

2003 • 135 citations

Studies on Down's syndrome in tissue culture. I. Growth rates protein contents of fibroblast cultures

1974 • 125 citations

Pituitary Hypoplasia inPttg^−/−Mice Is Protective forRb^+/−Pituitary Tumorigenesis

2005 • 122 citations

sSgo1, a Major Splice Variant of Sgo1, Functions in Centriole Cohesion Where It Is Regulated by Plk1

2008 • 115 citations

A primate virus generates transformed human cells by fusion

2005 • 98 citations

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein

2005 • 85 citations

Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line

2006 • 84 citations

Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice

2005 • 78 citations

Securin Associates with APCCdh1 in Prometaphase but its Destruction is Delayed by Rae1 and Nup98 until the Metaphase/Anaphase Transition

2006 • 62 citations

Mitotic Checkpoint Protein hsMAD2 as a Marker Predicting Liver Metastasis of Human Gastric Cancers

2001 • 58 citations

Mad2 and p53 expression profiles in colorectal cancer and its clinical significance

2003 • 56 citations

A Role for Polyploidy in the Tumorigenicity of Pim-1-Expressing Human Prostate and Mammary Epithelial Cells

2008 • 45 citations

Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

2008 • 42 citations

Studies on Down's syndrome in tissue culture

1973 • 33 citations

Cytogenetic biomarkers for human cancer

2008 • 23 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2005 • 13 citations

Many faces of separase regulation.

2008 • 11 citations