Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

The spindle-assembly checkpoint in space and time

2007 • 2,120 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

The anaphase promoting complex/cyclosome: a machine designed to destroy

2006 • 1,238 citations

Cell death by mitotic catastrophe: a molecular definition

2004 • 1,201 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1994 • 777 citations

Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

2006 • 709 citations

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

2004 • 702 citations

THE STRUCTURE AND FUNCTION OF SMC AND KLEISIN COMPLEXES

2005 • 597 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Does aneuploidy cause cancer?

2006 • 528 citations

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

2000 • 523 citations

Timing and Checkpoints in the Regulation of Mitotic Progression

2004 • 468 citations

Chromosome segregation and cancer: cutting through the mystery

2001 • 459 citations

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

2004 • 434 citations

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

2006 • 432 citations

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

2004 • 337 citations

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

2003 • 336 citations

CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity

1999 • 322 citations

PP2A Is Required for Centromeric Localization of Sgo1 and Proper Chromosome Segregation

2006 • 318 citations

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

2002 • 316 citations

Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores

1998 • 307 citations

The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad1 or Cdc20

2002 • 305 citations

The Mad2 spindle checkpoint protein has two distinct natively folded states

2004 • 293 citations

Phosphorylation of Cdc20 by Bub1 Provides a Catalytic Mechanism for APC/C Inhibition by the Spindle Checkpoint

2004 • 285 citations

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

2004 • 255 citations

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

2000 • 249 citations

Human Bub1 Defines the Persistent Cohesion Site along the Mitotic Chromosome by Affecting Shugoshin Localization

2005 • 245 citations

Activating and Silencing the Mitotic Checkpoint through CENP-E-Dependent Activation/Inactivation of BubR1

2003 • 239 citations

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase.

1994 • 231 citations

Spindle Checkpoint Protein Bub1 Is Required for Kinetochore Localization of Mad1, Mad2, Bub3, and Cenp-E, Independently of Its Kinase Activity

2001 • 228 citations

A dual role for Bub1 in the spindle checkpoint and chromosome congression

2005 • 206 citations

BUBR1 deficiency results in abnormal megakaryopoiesis

2003 • 182 citations

Heterozygous Deletion of Mitotic Arrest–Deficient Protein 1 (MAD1) Increases the Incidence of Tumors in Mice

2007 • 182 citations

The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation

2005 • 181 citations

Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival.

2002 • 178 citations

The Spindle Checkpoint of Budding Yeast Depends on a Tight Complex between the Mad1 and Mad2 Proteins

1999 • 175 citations

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

2006 • 173 citations

Chromosome segregation and genomic stability

2004 • 169 citations

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint

2003 • 161 citations

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

2005 • 158 citations

G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214.

1996 • 133 citations

The kinetochore and cancer: what's the connection?

2005 • 117 citations

Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model

2006 • 109 citations

Bub1 is essential for assembly of the functional inner centromere

2007 • 106 citations

BUB1 mediation of caspase-independent mitotic death determines cell fate

2007 • 104 citations

Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression.

1994 • 98 citations

Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma

2000 • 91 citations

Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint

2004 • 74 citations

Securin Associates with APCCdh1 in Prometaphase but its Destruction is Delayed by Rae1 and Nup98 until the Metaphase/Anaphase Transition

2006 • 62 citations

hBUB1 defects in leukemia and lymphoma cells

2002 • 62 citations

Bub1 Multitasking in Mitosis

2004 • 58 citations

Expression of <i>Bub1</i> Gene Correlates with Tumor Proliferating Activity in Human Gastric Carcinomas

2001 • 52 citations

Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus—their association with aneuploidy and neoplastic progression

2004 • 44 citations