The molecular basis of embryonic kidney development

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Hox genes in vertebrate development

1994 • 2,057 citations

WT-1 is required for early kidney development

1993 • 1,976 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Organogenesis of the kidney

1987 • 904 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

1995 • 587 citations

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo

1993 • 582 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Trans-filter induction of tubules in mouse metanephrogenic mesenchyme

1956 • 521 citations

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1995 • 502 citations

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 • 493 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

1990 • 479 citations

Organogenesis of the Kidney

1987 • 473 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1995 • 424 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Pax in development

1992 • 402 citations

Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility

1995 • 390 citations

The mouse Pax2 ^1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

1996 • 381 citations

Inductive Epithelio-mesenchymal Interaction in Cultured Organ Rudiments of the Mouse

1953 • 367 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

Renal agenesis and hypodysplasia in ret-k – mutant mice result from defects in ureteric bud development

1996 • 312 citations

Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips

1996 • 312 citations

Apoptosis in metanephric development.

1992 • 310 citations

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

1985 • 294 citations

Morphogenetic Interaction between Embryonic Mouse Tissues separated by a Membrane Filter

1953 • 285 citations

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

1993 • 284 citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

1995 • 280 citations

Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development

1993 • 273 citations

Repression of Pax-2 by WT1 during normal kidney development

1995 • 265 citations

Homeotic transformations and limb defects in Hox A11 mutant mice.

1993 • 260 citations

Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11

1994 • 253 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis.

1995 • 247 citations

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

1996 • 245 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.

1996 • 237 citations

Loss of p53 function through PAX-mediated transcriptional repression.

1995 • 236 citations

THE GENETICS OF WILMS’ TUMOR—A Case of Disrupted Development

1994 • 232 citations

The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.

1992 • 225 citations

PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms’ tumors

1992 • 223 citations

Embryonic Expression of Lim-1, the Mouse Homolog of Xenopus XLim-1, Suggests a Role in Lateral Mesoderm Differentiation and Neurogenesis

1994 • 215 citations

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

1996 • 213 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system

1994 • 198 citations

Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).

1996 • 189 citations

Mutation of PAX2 in two siblings with renal-coloboma syndrome

1995 • 168 citations

Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction

1992 • 168 citations

The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.

1996 • 168 citations

Basic fibroblast growth factor can mediate the early inductive events in renal development.

1995 • 164 citations

Induction of Kidney Epithelial Morphogenesis by Cells Expressing Wnt-1

1994 • 157 citations

Endogenous origin of glomerular endothelial and mesangial cells in grafts of embryonic kidneys

1996 • 151 citations

A Mouse Model of the Aniridia-Wilms Tumor Deletion Syndrome

1990 • 136 citations

The Wilms' tumor suppressor gene WT1 is negatively autoregulated.

1994 • 133 citations

Developmental patterns of PDGF B-chain, PDGF-receptor, and α-actin expression in human glomerulogenesis

1992 • 131 citations

Induction of Early Stages of Kidney Tubule Differentiation by Lithium Ions

1995 • 125 citations

Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development

1995 • 124 citations

The origin of the glomerular endothelium

1982 • 124 citations

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.

1996 • 123 citations

The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1).

1996 • 122 citations

Developmental expression of the RET protooncogene.

1994 • 119 citations

The evolution of WT1 sequence and expression pattern in the vertebrates.

1995 • 117 citations

An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling

1996 • 116 citations

Cell-Type-Specific Nuclear Translocation of Fibroblast Growth Factor-2 Isoforms during Chicken Kidney and Limb Morphogenesis

1994 • 108 citations

In vitro segregation of the metanephric nephron

1981 • 106 citations

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

1996 • 103 citations

Development and growth of mouse embryonic kidney in organ culture and modulation of development by soluble growth factor

1991 • 101 citations

The metanephric blastema differentiates into collecting system and nephron epithelia in vitro

1995 • 87 citations

THE MORPHOLOGICAL MANIFESTATIONS OF A DOMINANT MUTATION IN MICE AFFECTING TAIL AND UROGENITAL SYSTEM

1943 • 78 citations

Towards a genetic basis for kidney development

1994 • 77 citations

Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse

1996 • 70 citations

PAX8-mediated activation of the wt1 tumor suppressor gene.

1996 • 69 citations

Role of proteoglycans in renal development

1988 • 68 citations

Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of gf-4 and shh in the limb bud

1995 • 67 citations

Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation

1994 • 58 citations

Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice.

1996 • 57 citations

Transmission and spread of embryonic induction

1971 • 56 citations

Amphibian pronephric duct morphogenesis: segregation, cell rearrangement and directed migration of the Ambystoma duct rudiment

1981 • 49 citations

Heparin and heparan sulfate delimit nephron formation in fetal metanephric kidneys

1990 • 41 citations

Chondroitin sulfate proteoglycan synthesis and reutilization of β-d-xyloside-initiated chondroitin/dermatan sulfate glycosaminoglycans in fetal kidney branching morphogenesis

1989 • 37 citations

Molecular Interaction between Limb Deformity Proteins (Formins) and Src Family Kinases

1996 • 34 citations

The regulation of kidney development: new insights from an old model

1994 • 32 citations

Development in organ tissue culture of kidney rudiments from mutant mouse embryos

1963 • 30 citations

Post-translational Processing and Renal Expression of Mouse Indian Hedgehog

1997 • 28 citations

Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus.

1993 • 28 citations

Inductive interactions between the mesenchyme and the ureteric bud.

1996 • 26 citations

Malformations of the heart, kidney, palate, and skeleton in α-MHC-Hoxb-7 transgenic mice

1995 • 25 citations

The Formation of the Duct in Xenopus Involves Recruitment of Posterior Cells by Migrating Pronephric Duct Cells

1993 • 23 citations

Does the kidney express redundant or important molecules during nephrogenesis?

1996 • 16 citations

Denys-Drash syndrome: a role for the WT1 tumour suppressor gene in urogenital development

1994 • 9 citations

Molecular genetic analysis of Wnt signals in mouse development

1995 • 8 citations