C-erbB and the epidermal growth-factor receptor: a molecule with dual identity

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene

1987 • 448 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus

1982 • 318 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

Enemies within: the genesis of retrovirus oncogenes

1981 • 303 citations

Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes

1983 • 296 citations

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells

1984 • 296 citations

Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus

1983 • 289 citations

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

1985 • 284 citations

Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

1985 • 232 citations

Glycosylation of the epidermal growth factor receptor in A-431 cells. The contribution of carbohydrate to receptor function.

1984 • 229 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor

1985 • 216 citations

The ontogeny of epidermal growth factor receptors during mouse development

1984 • 213 citations

Structure of the Receptor for Insulin-Like Growth Factor II: The Puzzle Amplified

1988 • 206 citations

Growth factors: The epidermal growth factor receptor gene and its product

1984 • 187 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Epidermal growth factor, its receptor, and related proteins

1986 • 186 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

1986 • 171 citations

Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein

1983 • 167 citations

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

1986 • 167 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro

1985 • 160 citations

v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (Band 3) gene

1988 • 153 citations

Evidence for the multiple oncogenic potential of cloned leukemia virus: In vitro and in vivo studies with avian erythroblastosis virus

1976 • 151 citations

Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum.

1986 • 147 citations

A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas

1983 • 137 citations

Cell Surface Expression of v-fms-Coded Glycoproteins Is Required for Transformation

1984 • 131 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity

1983 • 127 citations

Antibodies to the Core Protein of Lymphadenopathy-Associated Virus (LAV) in Patients with AIDS

1984 • 125 citations

Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation.

1988 • 120 citations

Post-translational processing of the epidermal growth factor receptor. Glycosylation-dependent acquisition of ligand-binding capacity.

1985 • 119 citations

Complete sequence of the Rous sarcoma virus env gene: identification of structural and functional regions of its product

1983 • 119 citations

The product of the avian erythroblastosis virus erbB locus is a glycoprotein

1983 • 111 citations

Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs

1985 • 99 citations

Temperature-sensitive mutants of avian erythroblastosis virus: Surface expression of the erbB product correlates with transformation

1984 • 98 citations

A single point mutation in erbA restores the erythroid transforming potential of a mutant avian erythroblastosis virus (AEV) defective in both erbA and erbB oncogenes.

1987 • 87 citations

Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface

1984 • 86 citations

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions.

1987 • 85 citations

High-frequency transduction of c-erbB in avian leukosis virus-induced erythroblastosis

1985 • 84 citations

Epidermal Growth Factor: Mechanisms of Action

1982 • 81 citations

A Chimeric, Ligand-Binding v- erb B/EGF Receptor Retains Transforming Potential

1987 • 78 citations

Monoclonal antibodies to the transformation-specific glycoprotein encoded by the feline retroviral oncogene v-fms

1982 • 72 citations

Virus-specific RNAs in cells infected by avian myelocytomatosis virus and avian erythroblastosis virus: Modes of oncogene expression

1981 • 71 citations

Cell-free translation of avian erythroblastosis virus RNA yields two specific and distinct proteins with molecular weights of 75,000 and 40,000

1980 • 68 citations

Cell surface expression of v-fms-coded glycoproteins is required for transformation.

1984 • 66 citations

Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.

1988 • 64 citations

The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster.

1989 • 63 citations

Avian erythroblastosis virus produces two mRNA's

1980 • 60 citations

Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genes.

1986 • 58 citations

Site-specific mutagenesis of avian erythroblastosis virus: v-erb-A is not required for transformation of fibroblasts

1983 • 56 citations

Regulation of the epidermal growth factor receptor by phosphorylation

1985 • 54 citations

Phosphorylation of the erbB gene product from an avian erythroblastosis virus-transformed chick fibroblast cell line.

1985 • 50 citations

Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbB

1988 • 48 citations

Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase.

1985 • 47 citations

Effects of inhibitors of glycoprotein processing on the synthesis and biological activity of the erb B oncogene.

1985 • 46 citations

Mechanism of c-erbB transduction: newly released transducing viruses retain poly(A) tracts of erbB transcripts and encode C-terminally intact erbB proteins

1988 • 45 citations

Rous-associated virus 1-induced erythroleukemic cells exhibit a weakly transformed phenotype in vitro and release c-erbB-containing retroviruses unable to transform fibroblasts

1986 • 44 citations

Induction of angiosarcoma by a c-erbB transducing virus

1985 • 43 citations

A single amino acid substitution in v-erbB confers a thermolabile phenotype to ts167 avian erythroblastosis virus-transformed erythroid cells.

1986 • 43 citations

Subcellular localization of the v-erb-B protein, the product of a transforming gene of avian erythroblastosis virus

1984 • 42 citations

Subgenomic fragment of molecular cloned Friend murine leukemia virus DNA contains the gene(s) responsible for Friend murine leukemia virus-induced disease

1980 • 41 citations

Orientation of the v-erb-B gene product in the plasma membrane.

1986 • 34 citations

Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts.

1988 • 33 citations

Structural domains of the avian erythroblastosis virus erbB protein required for fibroblast transformation: dissection by in-frame insertional mutagenesis

1986 • 33 citations

Design of Retroviral Vectors for the Insertion of Foreign Deoxyribonucleic Acid Sequences into the Avian Germ Line

1986 • 32 citations

Defective v-erbB genes can be complemented by v-erbA in erythroblast and fibroblast transformation.

1987 • 32 citations

Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA

1985 • 31 citations

EXPERIMENTELLE STUDIEN ÜBER DIE BEZIEHUNGEN ZWISCHEN HÜHNERLEUKOSE UND SARKOM AN DER HAND EINES STAMMES VON ÜBERTRAGBARER LEUKOSE‐SARKOM‐KOMBINATION

1933 • 31 citations

Production and characterization of antisera specific for the erb-portion of p75, the presumptive transforming protein of avian erythroblastosis virus

1981 • 30 citations

Proviral-activated c-erbB is leukemogenic but not sarcomagenic: characterization of a replication-competent retrovirus containing the activated c-erbB

1988 • 30 citations

c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing.

1986 • 28 citations

I. BERICHT ÜBER NEUE ERFAHRUNQEN MIT EINEM STAMM HÜHNER‐ERYTHROLEUKOSE

1932 • 27 citations

Molecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virus.

1982 • 27 citations

Receptor Phosphorylation

2018 • 22 citations

Analysis of the autophosphorylation activity of transformation defective mutants of avian erythroblastosis virus

1986 • 21 citations

Transmembrane domain of the AEV erb B oncogene protein is not required for partial manifestation of the transformed phenotype

1987 • 17 citations

Mutagenesis of the avian erythroblastosis virus erbB coding region: an intact extracellular domain is not required for oncogenic transformation

1986 • 17 citations

Structure and expression of the chicken epidermal growth factor receptor gene locus

1986 • 16 citations

Biosynthesis and glycosylation of the epidermal growth factor receptor in human tumor-derived cell lines A431 and Hep 3B.

1986 • 16 citations

v-src mutations outside the carboxyl-coding region are not sufficient to fully activate transformation by pp60c-src in NIH 3T3 cells.

1988 • 13 citations

Mutation of a protein kinase C phosphorylation site in the erbB protein of avian erythroblastosis virus

1988 • 5 citations