Epidermal growth factor, its receptor, and related proteins

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

The Primary Structure of Epidermal Growth Factor

1972 • 533 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

1978 • 448 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1983 • 377 citations

Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells

1976 • 374 citations

Tumor-Promoting Phorbol Esters Inhibit Binding of Epidermal Growth Factor to Cellular Receptors

1978 • 355 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

The Stimulation of Epidermal Keratinization by a Protein Isolated from the Submaxillary Gland of the Mouse**From the Department of Biochemistry and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.

1963 • 310 citations

EFFECTS OF THE EXTRACT OF THE MOUSE SUBMAXILLARY SALIVARY GLANDS ON THE SYMPATHETIC SYSTEM OF MAMMALS*

1960 • 271 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.

1982 • 232 citations

Glycosylation of the epidermal growth factor receptor in A-431 cells. The contribution of carbohydrate to receptor function.

1984 • 229 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF

1982 • 206 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

Epidermal Growth Factor: Identification of a New Hormone in Human Urine

1975 • 186 citations

Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro

1985 • 160 citations

Biosynthesis of the epidermal growth factor receptor in A431 cells.

1984 • 156 citations

Mouse embryonic transforming growth factors related to those isolated from tumor cells.

1982 • 151 citations

Differential Expression of Transforming Growth Factor-α during Prenatal Development of the Mouse

1985 • 138 citations

The product of the avian erythroblastosis virus erbB locus is a glycoprotein

1983 • 111 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

The oligosaccharide moieties of the epidermal growth factor receptor in A-431 cells. Presence of complex-type N-linked chains that contain terminal N-acetylgalactosamine residues.

1985 • 106 citations

Similarity between the vaccinia virus 19K early protein and epidermal growth factor

1985 • 95 citations

Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

1985 • 94 citations

Characterization of the metabolic turnover of epidermal growth factor receptor protein in A‐431 cells

1984 • 94 citations

Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface

1984 • 86 citations

Co-translational excision of alpha-glucose and alpha-mannose in nascent vesicular stomatitis virus G protein.

1984 • 83 citations

Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor.

1984 • 83 citations

Blood group-active carbohydrate chains on the receptor for epidermal growth factor of A431 cells.

1984 • 78 citations

A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen.

1983 • 71 citations

Identification of an epidermal growth factor-related transforming growth factor from rat fetuses

1982 • 61 citations

Phosphorylation of the erbB gene product from an avian erythroblastosis virus-transformed chick fibroblast cell line.

1985 • 50 citations

Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation.

1985 • 49 citations

Effects of inhibitors of glycoprotein processing on the synthesis and biological activity of the erb B oncogene.

1985 • 46 citations

Different forms of the epidermal growth factor receptor kinase have different autophosphorylation sites

1985 • 39 citations

Inhibition by estradiol of binding and mitogenic effect of epidermal growth factor in primary cultures of Xenopus hepatocytes

1985 • 7 citations