The dynamics of HTLV-I and the CTL response

Infectious Diseases of Humans

1991 • 5,181 citations

Infectious diseases of humans

1992 • 2,265 citations

Population Dynamics of Immune Responses to Persistent Viruses

1996 • 1,218 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

Antigenic Diversity Thresholds and the Development of AIDS

1991 • 531 citations

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy

1999 • 417 citations

THE EVOLUTION OF VIRULENCE IN PATHOGENS WITH VERTICAL AND HORIZONTAL TRANSMISSION

1996 • 356 citations

Antigenic oscillations and shifting immunodominance in HIV-1 infections

1995 • 325 citations

Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

1989 • 289 citations

The population dynamics of vertically and horizontally transmitted parasites

1995 • 258 citations

Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis

1992 • 201 citations

The Evolution of Virulence in Pathogens with Vertical and Horizontal Transmission

1996 • 180 citations

Increased replication of HTLV‐I in HTLV‐I–associated myelopathy

1989 • 179 citations

Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study

1991 • 153 citations

High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis

1990 • 129 citations

Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens

1997 • 121 citations

Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously

1994 • 106 citations

Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy

1991 • 96 citations

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

1995 • 94 citations

Host response to intracellular pathogens

1997 • 93 citations

Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy

1993 • 91 citations

The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis

1994 • 89 citations

High Activated and Memory Cytotoxic T-cell Responses to HTLV-1 in Healthy Carriers and Patients with Tropical Spastic Paraparesis

1996 • 83 citations

Antibody titers to HTLV-I-p40tax protein and gag-env hybrid protein in HTLV-I-associated myelopathy/tropical spastic paraparesis: Correlation with increased HTLV-I proviral DNA load

1992 • 66 citations

DNA sequence analysis of the gene encoding the HTLV-I P21E transmembrane protein reveals inter- and intraisolate genetic heterogeneity

1992 • 50 citations

Presence of serum anti-human T-lymphotropic virus type I (HTLV-I) IgM antibodies means persistent active replication of HTLV-I in HTLV-I-associated myelopathy

1991 • 43 citations

The cytotoxic T-lymphocyte response to HTLV-I: the main determinant of disease?

1996 • 42 citations

Association of HTLV-I antibody profile of asymptomatic carriers with proviral DNA levels of peripheral blood mononuclear cells.

1994 • 39 citations

Increased Human T Lymphotropic Virus Type-1 (HTLV-1) Proviral Dna in Peripheral Blood Mononuclear Cells and Bronchoalveolar Lavage Cells from Japanese Patients with HTLV-1-Associated Myelopathy

1993 • 32 citations

Evolution in a chronic RNA virus infection: selection on HTLV-I tax protein differs between healthy carriers and patients with tropical spastic paraparesis

1996 • 23 citations