Development and Use of Multimeric Major Histocompatibility Complex Molecules

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

Rapid Effector Function in CD8+ Memory T Cells

1997 • 652 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

High Frequencies of Naive Melan-a/Mart-1–Specific Cd8+ T Cells in a Large Proportion of Human Histocompatibility Leukocyte Antigen (Hla)-A2 Individuals

1999 • 497 citations

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells

1999 • 466 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000 • 435 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses

2000 • 407 citations

MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen

1999 • 379 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

T-cell epitope mapping by flow cytometry

1998 • 295 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex

1998 • 281 citations

Attrition of T Cell Memory

1999 • 278 citations

Tetrameric HLA class I–minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

1999 • 277 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Tetrameric Complexes of Human Histocompatibility Leukocyte Antigen (HLA)-G Bind to Peripheral Blood Myelomonocytic Cells

1999 • 252 citations

Direct visualization of antigen-specific T cells: HTLV-1 Tax11–19- specific CD8⁺T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

1998 • 237 citations

Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood

1998 • 234 citations

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

2001 • 219 citations

Enrichment and detection of live antigen-specific CD4+ and CD8+ T cells based on cytokine secretion

1999 • 199 citations

Specificity of CTL Interactions with Peptide-MHC Class I Tetrameric Complexes Is Temperature Dependent

1999 • 197 citations

An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (Ctl)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific Ctls but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions

1999 • 197 citations

Direct enumeration ofBorrelia-reactive CD4 T cellsex vivoby using MHC class II tetramers

2000 • 149 citations

A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations.

1993 • 144 citations

Cutting Edge: In Situ Tetramer Staining of Antigen-Specific T Cells in Tissues

2000 • 143 citations

HLA-DQ Tetramers Identify Epitope-Specific T Cells in Peripheral Blood of Herpes Simplex Virus Type 2-Infected Individuals: Direct Detection of Immunodominant Antigen-Responsive Cells

2000 • 126 citations

Visualization and Characterization of Respiratory Syncytial Virus F-Specific CD8+ T Cells During Experimental Virus Infection

2001 • 115 citations

Human CD8+ CTL Specific for the Mycobacterial Major Secreted Antigen 85A

2000 • 114 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Expression of Recombinant HLA-DR2 Molecules

1996 • 99 citations

High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene

2000 • 97 citations

Cutting Edge: Lipid Raft Integrity Affects the Efficiency of MHC Class I Tetramer Binding and Cell Surface TCR Arrangement on CD8+ T Cells

2001 • 95 citations

Cutting Edge: Rapid Cloning of Tumor-Specific CTL Suitable for Adoptive Immunotherapy of Melanoma

1999 • 94 citations

CHARACTERIZATION OF CMVpp65-SPECIFIC CD8+ T LYMPHOCYTES USING MHC TETRAMERS IN KIDNEY TRANSPLANT PATIENTS AND HEALTHY PARTICIPANTS1

2000 • 94 citations

Assessing Cd8 T Cell Number and Dysfunction in the Presence of Antigen

2001 • 87 citations

In situ detection of virus- and tumor-specific T-cell immunity

2000 • 79 citations

Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells.

1980 • 75 citations

New Methods for Assessing T-Cell Responses

2000 • 70 citations

Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8⁺T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation

2001 • 68 citations

DIRECT VISUALIZATION AND QUANTITATION OF CYTOMEGALOVIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTES IN LIVER TRANSPLANT PATIENTS1

2000 • 63 citations

Generation and characterization of malaria-specific human CD8+ lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentationby liver cells

2000 • 51 citations

TCR avidity: it's not how strong you make it, it's how you make it strong

2001 • 42 citations

Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes and Protection Against Challenge in Rhesus Macaques Immunized with a Live Attenuated Simian Immunodeficiency Virus Vaccine

2000 • 41 citations

Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity

2000 • 37 citations

Direct Measurement of CD8+ T Cell Responses in Macaques Infected with Simian Immunodeficiency Virus

2000 • 37 citations

Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy

2000 • 32 citations