Primary Biliary Cirrhosis: The Molecule and the Mimic

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Primary Biliary Cirrhosis

1987 • 1,981 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.

1987 • 557 citations

The Presentation and Diagnosis of 100 Patients with Primary Biliary Cirrhosis

1973 • 510 citations

SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

1965 • 504 citations

Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications.

1966 • 419 citations

Use of designer recombinant mitochondrial antigens in the diagnosis of primary biliary cirrhosis

1992 • 349 citations

PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

1988 • 298 citations

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.

1988 • 283 citations

Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

1988 • 277 citations

Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

1988 • 259 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

1991 • 237 citations

Bone Loss and Reduced Osteoblast Function in Primary Biliary Cirrhosis

1985 • 230 citations

Bacteriuria and primary biliary cirrhosis.

1984 • 220 citations

Human immunoglobulin D segments encoded in tandem multigenic families

1981 • 219 citations

Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis

1979 • 213 citations

Detection of Autoantibodies to Recombinant Mitochondrial Proteins in Patients with Primary Biliary Cirrhosis

1989 • 206 citations

Primary biliary cirrhosis: Paradigm or paradox for autoimmunity

1991 • 204 citations

MITOCHONDRIAL ANTIBODIES IN PRIMARY BILIARY CIRRHOSIS

1967 • 203 citations

Osteoporosis in Primary Biliary Cirrhosis: Effects of 25-Hydroxyvitamin D3 Treatment

1982 • 200 citations

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

1980 • 199 citations

Mitochondrial Antibody in Primary Biliary Cirrhosis and Other Diseases

1972 • 199 citations

Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function.

1988 • 194 citations

The demography of primary biliary cirrhosis in ontario, canada

1990 • 186 citations

Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.

1993 • 185 citations

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice.

1989 • 177 citations

The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.

1990 • 174 citations

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours

1988 • 174 citations

Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope.

1990 • 173 citations

Primary biliary cirrhosis: an epidemiological study.

1980 • 172 citations

Association of Primary Sclerosing Cholangitis with HLA-DRw52a

1990 • 171 citations

Bone disease in primary biliary cirrhosis: histologic features and response to 25-hydroxyvitamin D.

1982 • 158 citations

Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region.

1990 • 150 citations

High Prevalence of Seroimmunologic Abnormalities in Relatives of Patients with Active Chronic Hepatitis or Primary Biliary Cirrhosis

1974 • 150 citations

RELATION BETWEEN ESCHERICHIA COLI R(ROUGH)-FORMS IN GUT, LIPID A IN LIVER, AND PRIMARY BILIARY CIRRHOSIS

1989 • 149 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

Primary Biliary Cirrhosis Showing a High Titer of Autoantibody

1958 • 144 citations

High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes.

1986 • 143 citations

HLA DRw8 and complement C4 deficiency as risk factors in primary biliary cirrhosis

1991 • 140 citations

Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.

1991 • 139 citations

Primary biliary cirrhosis: Associations with class II major histocompatibility complex antigens

1987 • 133 citations

Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.

1995 • 127 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

BONE DISEASE AND CALCIUM ABSORPTION IN PRIMARY BILIARY CIRRHOSIS With Special Reference to Vitamin-D Therapy

1968 • 119 citations

Ultrastructural immunocytochemical analysis of lymphocytes infiltrating bile duct epithelia in primary biliary cirrhosis

1986 • 118 citations

Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. Implications for the molecular basis of human autoimmune responses.

1989 • 115 citations

Antimitochondrial antibodies in primary biliary cirrhosis

1986 • 115 citations

The Epidemiology of Primary Biliary Cirrhosis in North-east England: an Increasingly Common Disease?

1990 • 113 citations

Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched-chain α-keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigen

1989 • 110 citations

Incidence and Prevalence of Primary Biliary Cirrhosis in a Denned Population in Sweden

1985 • 110 citations

Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis

1989 • 109 citations

Serological and histological diagnosis of primary biliary cirrhosis

1966 • 108 citations

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.

1990 • 107 citations

Analysis of hepatic T lymphocyte and immunoglobulin deposits in patients with primary biliary cirrhosis

1990 • 106 citations

Bone disease in primary biliary cirrhosis: Reversal of osteomalacia with oral 25-hydroxyvitamin D

1980 • 106 citations

Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis

1992 • 103 citations

ARE ANTIMITOCHONDRIAL ANTIBODIES IN PRIMARY BILIARY CIRRHOSIS INDUCED BY R(ROUGH)-MUTANTS OF ENTEROBACTERIACEAE?

1988 • 102 citations

Primary structure of the human M2 mitochondrial autoantigen of PBC : dihydrolipoamide acetyltransferase

1988 • 101 citations

T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): Oligoclonality of PBC‐derived T cell clones

1990 • 95 citations

Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex.

1989 • 85 citations

Hepatobiliary transport of plasma IgA in the mouse: contribution to clearance of intravascular IgA

1985 • 81 citations

Comparative epitope mapping of murine monoclonal and human autoantibodies to human PDH-E2, the major mitochondrial autoantigen of primary biliary cirrhosis.

1990 • 80 citations

Genes within the HLA class II region confer both predisposition and resistance to primary biliary cirrhosis

1994 • 80 citations

The Complex Nature of Mitochondrial Antibodies and Their Relation to Primary Biliary Cirrhosis

1981 • 80 citations

HLA Antigens in Japanese Patients with Primary Biliary Cirrhosis and Autoimmune Hepatitis

1983 • 79 citations

Primary Biliary Cirrhosis Associated with HLA—DRw3

1979 • 75 citations

Inhibition of α–Ketoglutarate Dehydrogenase Activity by A Distinct Population of Autoantibodies Recognizing Dihydrolipoamide Succinyltransferase in Primary Biliary Cirrhosis

1990 • 71 citations

A major histocompatibility complex Class III allotype (C4B 2) associated with Primary Biliary Cirrhosis (PBC)

1987 • 69 citations

The predominance of IgG3 and IgM isotype antimitochondrial autoantibodies against recombinant fused mitochondrial polypeptide in patients with primary biliary cirrhosis

1988 • 69 citations

Primary biliary cirrhosis in japan: National survey by the subcommittee on autoimmune hepatitis

1985 • 68 citations

Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis.

1993 • 68 citations

M4 and M9 Antibodies in the Overlap Syndrome of Primary Biliary Cirrhosis and Chronic Active Hepatitis: Epitopes or Epiphenomena?

1992 • 66 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

Primary biliary cirrhosis in twin sisters

1973 • 64 citations

HLA-DR antigens in primary biliary cirrhosis: lack of association.

1985 • 63 citations

Pathogenesis of steatorrhea in primary biliary cirrhosis

1985 • 62 citations

Mapping of epitopes on the La(SS-B) autoantigen of primary Sjögren's syndrome: identification of a cross-reactive epitope.

1990 • 61 citations

A lipoyl synthetic octadecapeptide of dihydrolipoamide acetyltransferase specifically recognized by anti-M2 autoantibodies in primary biliary cirrhosis.

1992 • 60 citations

DNA polymorphism of HLA class II genes in primary biliary cirrhosis

1992 • 58 citations

Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis

1989 • 56 citations

Distribution of dihydrolipoamide acetyltransferase (E2) in the liver and portal lymph nodes of patients with primary biliary cirrhosis: An immunohistochemical study

1991 • 55 citations

Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2

1990 • 53 citations

The epidemiology of primary biliary cirrhosis: A survey of mortality in England and Wales

1974 • 53 citations

Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the U1 ribonucleoprotein complex.

1990 • 52 citations

Fat digestion and exocrine pancreatic function in primary biliary cirrhosis

1984 • 50 citations

Inhibitory autoantibody to a conformational epitope of the pyruvate dehydrogenase complex, the major autoantigen in primary biliary cirrhosis

1991 • 44 citations

Familial occurrence of primary biliary cirrhosis associated with hypergammaglobulinemia in descendants: A family study

1980 • 42 citations

Are increased individual susceptibility and environmental factors both necessary for the development of primary biliary cirrhosis?

1979 • 42 citations

HLA Typing Using DNA Probes

1986 • 41 citations

Autoimmune Liver Diseases

1992 • 41 citations

M4 and M9 autoantigens in primary biliary cirrhosis — a negative study

1993 • 39 citations

Inhibition of enzyme function by human autoantibodies to an autoantigen pyruvate dehydrogenase E2; different epitope for spontaneous human and induced rabbit autoantibodies

1990 • 37 citations

Autoantibody against dihydrolipoamide dehydrogenase, the E3 subunit of the 2-oxoacid dehydrogenase complexes: Significance for primary biliary cirrhosis

1991 • 36 citations

Histocompatibility antigens in primary biliary cirrhosis.

1987 • 36 citations

Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis differ for mammalian, yeast and bacterial enzymes: Implications for molecular mimicry

1994 • 35 citations

Antimitochondrial antibodies in kindreds of patients with primary biliary cirrhosis: Antimitochondrial antibodies are unique to clinical disease and are absent in asymptomatic family members

1992 • 34 citations

Evidence for the cell-surface localization of antigens cross-reacting with the “mitochondrial antibodies” of primary biliary cirrhosis

1987 • 33 citations

The role of the liver in Translocation of IgA into the Gastrointestinal Tract

1989 • 32 citations

Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology.

1994 • 31 citations

Primary biliary cirrhosis: Considerations on pathogenesis based on identification of the M2 autoantigens

1990 • 30 citations

Nature of the Mitochondrial Antigens of Primary Biliary Cirrhosis and Their Possible Relationships to the Etiology of the Disease

1989 • 29 citations

Hepatic osteodystrophy: Outlook good but some problems unsolved

1980 • 29 citations

Mitochondrial and other tissue autoantibodies in patients with biological false positive reactions for syphilis.

1970 • 28 citations

Immunological Parameters, Viral Antibodies, and Biochemical and Histological Findings in Relatives of Patients with Chronic Active Hepatitis and Primary Biliary Cirrhosis

1976 • 27 citations

Comparative Immunoreactive Profiles of Japanese and American Patients with Primary Biliary Cirrhosis against Mitochondrial Autoantigens

1992 • 26 citations

Subclasses of Immunoglobulins and Autoantibodies in Autoimmune Diseases

1993 • 26 citations

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis

1992 • 26 citations

Molecular characterization of the mitochondrial autoantigens in primary biliary cirrhosis

1991 • 26 citations

Augmentation of the Antibody Response by Lipoic Acid in Mice I. Analysis of the Mode of Action in an In Vitro Culture System

1986 • 25 citations

Antibody binding and inhibition of pyruvate dehydrogenase (PDH) in sera from patients with primary biliary cirrhosis

1990 • 22 citations

Heterogeneity of the TCR Repertoire in Synovial Fluid T Lymphocytes Responding to BCG in a Patient with Early Rheumatoid Arthritis

1993 • 19 citations

Low molecular weight IgM

1986 • 18 citations

Primary biliary cirrhosis

1970 • 18 citations

Gastric carcinoma combined with distant gastric ulcer

1976 • 15 citations

The Relative Affinity of Recombinant Dihydrolipoamide Transacetylase for Autoantibodies in Primary Biliary Cirrhosis

1990 • 14 citations

Plasma membrane association of primary biliary cirrhosis mitochondrial marker antigen M2

1991 • 11 citations

Cloned autoantigens in the study and diagnosis of autoimmune diseases.

1989 • 11 citations

The ubiquitin pathway of protein degradation and proteolysis of ubiquitin-protein conjugates

1991 • 10 citations

Uridine diphosphoglucose restores lipocyte proliferation in the regenerating liver of ethanol-treated rats

1992 • 8 citations

Cloning and identification of autoantigens

1992 • 3 citations