Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Easy identification of cDNA clones.

1983 • 587 citations

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.

1987 • 557 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type

1971 • 410 citations

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.

1988 • 283 citations

Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

1988 • 259 citations

Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function.

1988 • 194 citations

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

1987 • 146 citations

ATPASE-ASSOCIATED ANTIGEN (M2): MARKER ANTIGEN FOR SEROLOGICAL DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

1982 • 143 citations

Primary biliary cirrhosis: Associations with class II major histocompatibility complex antigens

1987 • 133 citations

Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched-chain α-keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigen

1989 • 110 citations

Primary structure of the human M2 mitochondrial autoantigen of PBC : dihydrolipoamide acetyltransferase

1988 • 101 citations

Primary biliary cirrhosis and mitochondrial autoantigens—insights from molecular biology

1988 • 99 citations

Regulation of experimental autoimmune thyroiditis: Mapping of susceptibility to the I-A subregion of the mouse H-2

1982 • 97 citations

The predominance of IgG3 and IgM isotype antimitochondrial autoantibodies against recombinant fused mitochondrial polypeptide in patients with primary biliary cirrhosis

1988 • 69 citations

[65] Pyruvate dehydrogenase complex from bovine kidney and heart

1982 • 65 citations

Characterization of the in vitro murine T-cell proliferative responses to murine and human thyroglobulins in thyroiditis-susceptible and -resistant mice

1985 • 53 citations

Detection of conserved and nonconserved epitopes on coxsackievirus B4: Frequency of antigenic change

1985 • 51 citations

Molecular cloning of the liver-specific rat F antigen.

1987 • 41 citations

Evidence for the cell-surface localization of antigens cross-reacting with the “mitochondrial antibodies” of primary biliary cirrhosis

1987 • 33 citations

Augmentation of the Antibody Response by Lipoic Acid in Mice I. Analysis of the Mode of Action in an In Vitro Culture System

1986 • 25 citations

Spontaneous "primary biliary cirrhosis" in rabbits.

1982 • 22 citations

Spontaneous “primary biliary cirrhosis” in rabbits

1982 • 19 citations

The nature of the autoantibody response to thyroglobulin in murine strains with high or low susceptibility to the experimental induction of autoimmune thyroiditis.

1982 • 13 citations

Production of histological changesmimicking primary biliary cirrhosis in rabbits by immunization with bile duct antigen

1986 • 7 citations

Does the amount of thyroglobulin antigen influence the severity and genetic control of murine autoimmune thyroiditis?

1983 • 4 citations

Primary biliary cirrhosis like lesions following experimental autoimmunization.

1982 • 3 citations