Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

1978 • 1,117 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Enhanced autoradiographic detection of ³²P and ¹²⁵I using intensifying screens and hypersensitized film

1977 • 947 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro.

1977 • 711 citations

A physical map of the DNA regions flanking the rabbit β-globin gene

1977 • 654 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

The arrangement and rearrangement of antibody genes

1978 • 277 citations

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments

1980 • 272 citations

A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13

1979 • 257 citations

The role of gene deletion in the immunoglobulin heavy chain switch

1980 • 164 citations

Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA

1978 • 71 citations

Immunoglobulin light chain mRNA is processed from large nuclear RNA.

1978 • 66 citations

Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA

1978 • 63 citations

Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity

1980 • 62 citations

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome.

1979 • 54 citations

Immunoglobulin expression and synthesis by human haemic cell lines.

1977 • 41 citations

The sequence at the 3' terminus of mouse immunoglobulin secreted mu chain messenger RNA determined from cloned cDNA.

1980 • 16 citations