Inhibitory autoantibody to a conformational epitope of the pyruvate dehydrogenase complex, the major autoantigen in primary biliary cirrhosis

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.

1987 • 557 citations

Epitopes on protein antigens: Misconceptions and realities

1990 • 532 citations

SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

1965 • 504 citations

Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen

1987 • 420 citations

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

1989 • 363 citations

PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS

1988 • 298 citations

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.

1988 • 283 citations

Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.

1988 • 277 citations

Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

1988 • 259 citations

Cloning of the human cDNA for the U1 RNA-associated 70K protein.

1986 • 235 citations

Centrifugation: A Practical Approach

1985 • 222 citations

Primary Biliary Cirrhosis: A Model Autoimmune Disease

1983 • 220 citations

Detection of Autoantibodies to Recombinant Mitochondrial Proteins in Patients with Primary Biliary Cirrhosis

1989 • 206 citations

MITOCHONDRIAL ANTIBODIES IN PRIMARY BILIARY CIRRHOSIS

1967 • 203 citations

Purification of 2-oxo acid dehydrogenase multienzyme complexes from ox heart by a new method

1980 • 201 citations

Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen.

1989 • 197 citations

Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function.

1988 • 194 citations

Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope.

1990 • 173 citations

Mitochondrial antibodies in primary biliary cirrhosis: Species and nonspecies specific determinants of M2 antigen

1985 • 161 citations

Primary Biliary Cirrhosis Showing a High Titer of Autoantibody

1958 • 144 citations

Reactivity of anti-mitochondrial autoantibodies in primary biliary cirrhosis: definition of two novel mitochondrial polypeptide autoantigens.

1985 • 138 citations

Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex

1989 • 125 citations

Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex.

1989 • 85 citations

Inhibition of α–Ketoglutarate Dehydrogenase Activity by A Distinct Population of Autoantibodies Recognizing Dihydrolipoamide Succinyltransferase in Primary Biliary Cirrhosis

1990 • 71 citations

[65] Pyruvate dehydrogenase complex from bovine kidney and heart

1982 • 65 citations

Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products.

1990 • 65 citations

Heterogeneity of Antimitochondrial Antibodies

1989 • 63 citations

The E1 α and β Subunits of the Pyruvate Dehydrogenase Complex are M2‘d’ and M2‘e’ Autoantigens in Primary Biliary Cirrhosis

1989 • 62 citations

Mapping of epitopes on the La(SS-B) autoantigen of primary Sjögren's syndrome: identification of a cross-reactive epitope.

1990 • 61 citations

Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins.

1988 • 54 citations

Primary biliary cirrhosis.

1987 • 37 citations

Inhibition of enzyme function by human autoantibodies to an autoantigen pyruvate dehydrogenase E2; different epitope for spontaneous human and induced rabbit autoantibodies

1990 • 37 citations

Centrifugation: a practical approach (2nd Edn)

1985 • 36 citations

Antinuclear antibodies as molecular and diagnostic probes

1988 • 14 citations

Primary biliary cirrhosis

1986 • 6 citations

Identity of the M2 autoantigens in primary biliary cirrhosis

1989 • 3 citations